Detailed information NTG0997373

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ABC811_RS11095
• Genome accession: NZ_CP155535
• Coordinates: 2143257..2144009 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PJ755/1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2138257..2149009

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC811_RS11070 (ABC811_11070)	-	2139270..2140617 (-)	1348	Protein_2143	IS3 family transposase	-
ABC811_RS11075 (ABC811_11075)	-	2140690..2142293 (-)	1604	Protein_2144	YhgE/Pip domain-containing protein	-
ABC811_RS11080 (ABC811_11080)	-	2142472..2143014 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ABC811_RS11095 (ABC811_11095)	comE	2143257..2144009 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ABC811_RS11100 (ABC811_11100)	comD/comD1	2144006..2145331 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
ABC811_RS11105 (ABC811_11105)	comC/comC1	2145352..2145477 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ABC811_RS11115 (ABC811_11115)	rlmH	2145759..2146238 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABC811_RS11120 (ABC811_11120)	htrA	2146421..2147602 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
ABC811_RS11125 (ABC811_11125)	spo0J	2147660..2148418 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=997373 ABC811_RS11095 WP_000866065.1 2143257..2144009(-) (comE) [Streptococcus pneumoniae strain PJ755/1]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=997373 ABC811_RS11095 WP_000866065.1 2143257..2144009(-) (comE) [Streptococcus pneumoniae strain PJ755/1]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408