Detailed information NTG0099660

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QMM73_RS09595
• Genome accession: NZ_AP027135
• Coordinates: 1950462..1951505 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JP089
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945462..1956505

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM73_RS09565 (JP089_17780)	-	1945884..1947140 (-)	1257	WP_001793428.1	aminopeptidase	-
QMM73_RS09570 (JP089_17790)	-	1947143..1947343 (-)	201	WP_000180460.1	DUF1128 family protein	-
QMM73_RS09575 (JP089_17800)	-	1947490..1947954 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QMM73_RS09580 (JP089_17810)	-	1947961..1948236 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QMM73_RS09585 (JP089_17820)	-	1948514..1949731 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
QMM73_RS09590 (JP089_17830)	vraR	1949843..1950472 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QMM73_RS09595 (JP089_17840)	vraS	1950462..1951505 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QMM73_RS09600 (JP089_17850)	liaF	1951502..1952203 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QMM73_RS09605 (JP089_17860)	-	1952218..1952604 (-)	387	WP_001110179.1	hypothetical protein	-
QMM73_RS09610 (JP089_17870)	map	1952821..1953579 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QMM73_RS09615 (JP089_17880)	-	1953995..1954981 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
QMM73_RS09620 (JP089_17890)	-	1955412..1955825 (-)	414	WP_001837236.1	hypothetical protein	-
QMM73_RS09625	-	1955854..1955965 (-)	112	Protein_1856	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=99660 QMM73_RS09595 WP_001017131.1 1950462..1951505(-) (vraS) [Staphylococcus aureus strain JP089]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=99660 QMM73_RS09595 WP_001017131.1 1950462..1951505(-) (vraS) [Staphylococcus aureus strain JP089]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1