Detailed information NTG0994644

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: AAFU62_RS02970
• Genome accession: NZ_CP154891
• Coordinates: 588282..589319 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 318231
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 583282..594319

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAFU62_RS02945 (AAFU62_02945)	-	583546..584877 (+)	1332	WP_009880963.1	dipeptidase	-
AAFU62_RS02950 (AAFU62_02950)	arcC	584897..585847 (+)	951	WP_063631992.1	carbamate kinase	-
AAFU62_RS02955 (AAFU62_02955)	asnA	586160..587152 (+)	993	WP_012560825.1	aspartate--ammonia ligase	-
AAFU62_RS02960 (AAFU62_02960)	rsmD	587275..587814 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
AAFU62_RS02965 (AAFU62_02965)	coaD	587804..588295 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
AAFU62_RS02970 (AAFU62_02970)	sepM	588282..589319 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
AAFU62_RS02975 (AAFU62_02975)	-	589733..590710 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
AAFU62_RS02980 (AAFU62_02980)	-	591158..591778 (+)	621	WP_227877841.1	YutD family protein	-
AAFU62_RS02985 (AAFU62_02985)	rlmN	591782..592861 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
AAFU62_RS02990 (AAFU62_02990)	-	592943..593569 (-)	627	WP_010922497.1	A24 family peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=994644 AAFU62_RS02970 WP_010922499.1 588282..589319(+) (sepM) [Streptococcus pyogenes strain 318231]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=994644 AAFU62_RS02970 WP_010922499.1 588282..589319(+) (sepM) [Streptococcus pyogenes strain 318231]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693