Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   EW023_RS06340 Genome accession   NZ_LR130239
Coordinates   1249414..1250451 (-) Length   345 a.a.
NCBI ID   WP_010922499.1    Uniprot ID   A0A0H2UVK2
Organism   Streptococcus pyogenes strain PS003 isolate PS003     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 1244414..1255451
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW023_RS06320 - 1245164..1245790 (+) 627 WP_010922497.1 prepilin peptidase -
  EW023_RS06325 rlmN 1245872..1246951 (-) 1080 WP_002992788.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  EW023_RS06330 - 1246955..1247575 (-) 621 WP_002992791.1 YutD family protein -
  EW023_RS06335 - 1248023..1249000 (-) 978 WP_002994809.1 LacI family DNA-binding transcriptional regulator -
  EW023_RS06340 sepM 1249414..1250451 (-) 1038 WP_010922499.1 SepM family pheromone-processing serine protease Regulator
  EW023_RS06345 coaD 1250438..1250929 (-) 492 WP_002983821.1 pantetheine-phosphate adenylyltransferase -
  EW023_RS06350 rsmD 1250919..1251458 (-) 540 WP_050336299.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  EW023_RS06355 asnA 1251581..1252573 (-) 993 WP_002983817.1 aspartate--ammonia ligase -
  EW023_RS06360 arcC 1252886..1253836 (-) 951 WP_015057899.1 carbamate kinase -
  EW023_RS06365 - 1253856..1255187 (-) 1332 WP_023612508.1 dipeptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37541.24 Da        Isoelectric Point: 9.6692

>NTDB_id=994436 EW023_RS06340 WP_010922499.1 1249414..1250451(-) (sepM) [Streptococcus pyogenes strain PS003 isolate PS003]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=994436 EW023_RS06340 WP_010922499.1 1249414..1250451(-) (sepM) [Streptococcus pyogenes strain PS003 isolate PS003]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterProScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UVK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

69.275

100

0.693

Multiple sequence alignment