Detailed information NTG0994436

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: AAYT23_RS02315
• Genome accession: NZ_CP154877
• Coordinates: 450048..450635 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 20234295
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 445048..455635

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAYT23_RS02290 (AAYT23_02275)	-	445512..446852 (+)	1341	WP_001017622.1	sensor histidine kinase	-
AAYT23_RS02295 (AAYT23_02280)	blpC	446894..447049 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
AAYT23_RS02300 (AAYT23_02285)	-	447106..448467 (-)	1362	WP_001069074.1	bacteriocin secretion accessory protein	-
AAYT23_RS02305 (AAYT23_02290)	comA/nlmT	448478..449125 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
AAYT23_RS02310 (AAYT23_02295)	comA/nlmT	449141..450154 (-)	1014	WP_318528993.1	ABC transporter transmembrane domain-containing protein	Regulator
AAYT23_RS02315 (AAYT23_02300)	comA/nlmT	450048..450635 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
AAYT23_RS02320 (AAYT23_02305)	blpI	450917..451114 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
AAYT23_RS02325 (AAYT23_02310)	blpJ	451581..451850 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
AAYT23_RS02330 (AAYT23_02315)	blpK	451919..452167 (+)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
AAYT23_RS02335 (AAYT23_02320)	cipB	452411..452560 (+)	150	WP_001836413.1	bacteriocin-like peptide BlpO	Regulator
AAYT23_RS02340	-	452596..452661 (+)	66	Protein_459	ComC/BlpC family peptide pheromone/bacteriocin	-
AAYT23_RS02345 (AAYT23_02325)	-	452664..452783 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
AAYT23_RS02350 (AAYT23_02330)	-	453264..453622 (+)	359	Protein_461	immunity protein	-
AAYT23_RS02355 (AAYT23_02335)	-	454251..454634 (+)	384	WP_000877381.1	hypothetical protein	-
AAYT23_RS02360 (AAYT23_02340)	-	454686..455375 (+)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=994436 AAYT23_RS02315 WP_000205166.1 450048..450635(-) (comA/nlmT) [Streptococcus pneumoniae strain 20234295]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=994436 AAYT23_RS02315 WP_000205166.1 450048..450635(-) (comA/nlmT) [Streptococcus pneumoniae strain 20234295]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497