Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   EW024_RS05895 Genome accession   NZ_LR130237
Coordinates   1152211..1152873 (-) Length   220 a.a.
NCBI ID   WP_002995626.1    Uniprot ID   A0A0H2UV22
Organism   Streptococcus pyogenes strain SP444 isolate SP444     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1147211..1157873
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW024_RS05875 - 1147861..1148007 (-) 147 WP_011528767.1 hypothetical protein -
  EW024_RS05880 sodA 1148174..1148779 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  EW024_RS05885 holA 1148876..1149916 (-) 1041 WP_011017949.1 DNA polymerase III subunit delta -
  EW024_RS05890 comEC/celB 1149987..1152230 (-) 2244 WP_011528768.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EW024_RS05895 comEA/celA/cilE 1152211..1152873 (-) 663 WP_002995626.1 ComEA family DNA-binding protein Machinery gene
  EW024_RS05900 - 1153073..1153813 (-) 741 WP_021299345.1 lysophospholipid acyltransferase family protein -
  EW024_RS05905 - 1153931..1154707 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  EW024_RS05910 - 1154697..1154975 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  EW024_RS05915 - 1154999..1157000 (-) 2002 Protein_1088 KUP/HAK/KT family potassium transporter -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 24623.45 Da        Isoelectric Point: 6.7451

>NTDB_id=994235 EW024_RS05895 WP_002995626.1 1152211..1152873(-) (comEA/celA/cilE) [Streptococcus pyogenes strain SP444 isolate SP444]
MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLK
GAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD

Nucleotide


Download         Length: 663 bp        

>NTDB_id=994235 EW024_RS05895 WP_002995626.1 1152211..1152873(-) (comEA/celA/cilE) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGTTAGACGAATTATTAATTAAAGGAAAATCGTTTTTGAGAGAGCGGTATTTTCTGCCATACCTAATTAGTCTTTTATT
AGGACTTTTTCTAATACTAAGCTTCAGTTTTTTGTTCTGGGGAAATAGGCAGAGCAAGGCAGCCGTTCCTGCTTTGAGAG
AAATATCGCCTGTGAAACAGCAGGTTAGTGAAGAAAAAAAGGAAATTCAAGAAGATAACAGTATTTTAGTGGATTTAAAA
GGCGCCGTACAAAAAGAGGGAGTTTATAAGCTAACTGCTAGCAGTCGTGTGCGAGATGTCATTGAACTAGCTGGAGGCCT
AACTTCAGAAGCTGATAAACATGCTATTAATTTTGCAGAAAAACTAACTGATGAGCAAGTTGTTTATGTACCTAAACAAG
GAGAAGAGATTTCTGTGCTACCAAGATCATTAGTTTCTGGTAAAAAAGAAACTGCCAGCAAGGATCAGTCAAAGGTTCAT
ATTAATAAGGCCAGCTTAGAAGAACTACAACATATCCCAGGTATTGGTGCTAAAAGAGCTCAGGATATTATTGATATGAG
AGATAAGTTAGGTGGTTTTAAAGCGTTAGAAGATCTCCGTCAGGTTTCGGGGATTGGCGAAAAAACGCTCGAGAAATTAA
AAGATGACATTTTCTTGGACTAA

Domains

Predicted by InterProScan.

SLBB domain (SLBB)

(77-130)

Helix-hairpin-helix motif (HHH_3)

(156-217)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UV22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

42.995

94.091

0.405

Multiple sequence alignment