Detailed information NTG0994116

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: EW021_RS03685
• Genome accession: NZ_LR130236
• Coordinates: 712886..714985 (-)
• Length: 699 a.a.
• NCBI ID: WP_010922175.1
• Uniprot ID: A0A0H2UU50
• Organism: Streptococcus pyogenes strain 5448 isolate 5448
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 707886..719985

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW021_RS03655	-	708363..709202 (+)	840	WP_010922172.1	thymidylate synthase	-
EW021_RS03660	-	709282..709779 (+)	498	WP_011285487.1	dihydrofolate reductase	-
EW021_RS03665	-	709799..709969 (+)	171	WP_002984950.1	hypothetical protein	-
EW021_RS03670	clpX	710099..711328 (+)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
EW021_RS03675	yihA	711338..711937 (+)	600	WP_002984945.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
EW021_RS03680	-	712085..712828 (+)	744	WP_002984942.1	hypothetical protein	-
EW021_RS03685	clpC	712886..714985 (-)	2100	WP_010922175.1	AAA family ATPase	Regulator
EW021_RS03690	rpiA	715364..716047 (+)	684	WP_010922176.1	ribose-5-phosphate isomerase RpiA	-
EW021_RS03695	-	716124..717335 (+)	1212	WP_002994004.1	phosphopentomutase	-
EW021_RS03700	arsC	717354..717794 (+)	441	WP_010922177.1	arsenate reductase (glutaredoxin)	-
EW021_RS03705	-	717778..718587 (+)	810	WP_010922178.1	purine-nucleoside phosphorylase	-
EW021_RS03710	deoD	719250..719963 (+)	714	WP_002990147.1	purine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 699 a.a.
• Molecular weight: 77347.42 Da
• Isoelectric Point: 5.6670

>NTDB_id=994116 EW021_RS03685 WP_010922175.1 712886..714985(-) (clpC) [Streptococcus pyogenes strain 5448 isolate 5448]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide

• Length: 2100 bp

>NTDB_id=994116 EW021_RS03685 WP_010922175.1 712886..714985(-) (clpC) [Streptococcus pyogenes strain 5448 isolate 5448]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAATCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGGGCAGGTTTTGATGATGGTAAACGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TTATTACACTTCTTCTACAAGTATTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAGTTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTACTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (607-678)

• ATPase family associated with various cellular activities (AAA) (AAA) (118-250)

• AAA domain (Cdc48 subfamily) (AAA_2) (443-600)

• AAA lid domain (AAA_lid_9) (259-353)

3D structure

• AlphaFold DB: A0A0H2UU50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	46.942	100	0.472
clpE	Streptococcus mutans UA159	49.068	92.132	0.452
clpE	Streptococcus pneumoniae TIGR4	49.278	89.127	0.439
clpE	Streptococcus pneumoniae Rx1	49.278	89.127	0.439
clpE	Streptococcus pneumoniae D39	49.278	89.127	0.439
clpE	Streptococcus pneumoniae R6	49.278	89.127	0.439
clpC	Bacillus subtilis subsp. subtilis str. 168	44.962	95.136	0.428
clpC	Streptococcus pneumoniae Rx1	42.025	93.276	0.392
clpC	Streptococcus pneumoniae D39	42.025	93.276	0.392
clpC	Streptococcus thermophilus LMD-9	42.947	91.273	0.392
clpC	Streptococcus thermophilus LMG 18311	42.79	91.273	0.391
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.501	93.419	0.388
clpC	Streptococcus pneumoniae TIGR4	43.016	90.129	0.388
clpC	Streptococcus mutans UA159	41.875	91.559	0.383