Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   AAIS09_RS06200 Genome accession   NZ_CP154595
Coordinates   1234951..1235688 (-) Length   245 a.a.
NCBI ID   WP_000782680.1    Uniprot ID   A0A0B7L5A1
Organism   Streptococcus pneumoniae strain serotype 4     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1229951..1240688
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAIS09_RS06185 (AAIS09_06170) msrB 1231455..1232393 (-) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -
  AAIS09_RS06190 (AAIS09_06175) thrB 1232643..1233512 (-) 870 WP_000692438.1 homoserine kinase -
  AAIS09_RS06195 (AAIS09_06180) - 1233514..1234800 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  AAIS09_RS06200 (AAIS09_06185) mecA 1234951..1235688 (-) 738 WP_000782680.1 adaptor protein MecA Regulator
  AAIS09_RS06205 (AAIS09_06190) - 1235888..1236922 (-) 1035 WP_000461502.1 hypothetical protein -
  AAIS09_RS06210 (AAIS09_06195) - 1236951..1238384 (-) 1434 WP_000565088.1 O-antigen polysaccharide polymerase Wzy family protein -
  AAIS09_RS06215 (AAIS09_06200) - 1238400..1239386 (-) 987 WP_000446980.1 glycosyltransferase family 2 protein -
  AAIS09_RS06220 (AAIS09_06205) - 1239388..1240491 (-) 1104 WP_000225892.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28409.24 Da        Isoelectric Point: 4.0199

>NTDB_id=993683 AAIS09_RS06200 WP_000782680.1 1234951..1235688(-) (mecA) [Streptococcus pneumoniae strain serotype 4]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVVFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=993683 AAIS09_RS06200 WP_000782680.1 1234951..1235688(-) (mecA) [Streptococcus pneumoniae strain serotype 4]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGTTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5A1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment