Detailed information NTG0993576

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SP119_RS06650
• Genome accession: NZ_LR031521
• Coordinates: 1260864..1261901 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A0H2UVK2
• Organism: Streptococcus pyogenes strain S119 isolate S119
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1255864..1266901

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP119_RS06630 (SP119_1260)	-	1256615..1257241 (+)	627	WP_010922497.1	prepilin peptidase	-
SP119_RS06635 (SP119_1261)	rlmN	1257323..1258402 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SP119_RS06640 (SP119_1262)	-	1258406..1259026 (-)	621	WP_011285637.1	YutD family protein	-
SP119_RS06645 (SP119_1263)	-	1259474..1260450 (-)	977	Protein_1241	LacI family DNA-binding transcriptional regulator	-
SP119_RS06650 (SP119_1264)	sepM	1260864..1261901 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SP119_RS06655 (SP119_1265)	coaD	1261888..1262379 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SP119_RS06660 (SP119_1266)	rsmD	1262369..1262908 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SP119_RS06665 (SP119_1267)	asnA	1263031..1264023 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
SP119_RS06670 (SP119_1268)	arcC	1264336..1265286 (-)	951	WP_010922501.1	carbamate kinase	-
SP119_RS06675 (SP119_1269)	-	1265306..1266637 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=993576 SP119_RS06650 WP_010922499.1 1260864..1261901(-) (sepM) [Streptococcus pyogenes strain S119 isolate S119]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=993576 SP119_RS06650 WP_010922499.1 1260864..1261901(-) (sepM) [Streptococcus pyogenes strain S119 isolate S119]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterProScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A0H2UVK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693