Detailed information NTG0987416

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SL323_RS10420
• Genome accession: NZ_CP152120
• Coordinates: 2078233..2079276 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN62-2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2073233..2084276

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SL323_RS10390 (SL323_10395)	-	2073651..2074907 (-)	1257	WP_001795438.1	aminopeptidase	-
SL323_RS10395 (SL323_10400)	-	2074910..2075110 (-)	201	WP_000180461.1	DUF1128 family protein	-
SL323_RS10400 (SL323_10405)	-	2075257..2075721 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SL323_RS10405 (SL323_10410)	-	2075728..2076003 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SL323_RS10410 (SL323_10415)	-	2076281..2077498 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
SL323_RS10415 (SL323_10420)	vraR	2077614..2078243 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SL323_RS10420 (SL323_10425)	vraS	2078233..2079276 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SL323_RS10425 (SL323_10430)	liaF	2079273..2079974 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SL323_RS10430 (SL323_10435)	-	2079989..2080375 (-)	387	WP_001110179.1	hypothetical protein	-
SL323_RS10435 (SL323_10440)	map	2080592..2081350 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SL323_RS10440 (SL323_10445)	-	2081878..2082864 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SL323_RS10445 (SL323_10450)	-	2083354..2083767 (-)	414	WP_001549145.1	hypothetical protein	-
SL323_RS10450 (SL323_10455)	-	2083796..2083906 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=987416 SL323_RS10420 WP_001017131.1 2078233..2079276(-) (vraS) [Staphylococcus aureus strain BSN62-2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=987416 SL323_RS10420 WP_001017131.1 2078233..2079276(-) (vraS) [Staphylococcus aureus strain BSN62-2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1