Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   R8507_RS08440 Genome accession   NZ_AP026925
Coordinates   1649283..1649942 (+) Length   219 a.a.
NCBI ID   WP_000565001.1    Uniprot ID   A0A0B7M7B9
Organism   Streptococcus pneumoniae strain PZ900700097     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1644283..1654942
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8507_RS08400 (PC0094_16700) mgaSpn 1644544..1646025 (-) 1482 WP_001205281.1 virulence factor transcriptional regulator MgaSpn -
  R8507_RS08405 (PC0094_16710) - 1646468..1646632 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  R8507_RS08410 amaP 1646716..1647282 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  R8507_RS08415 (PC0094_16730) - 1647294..1647464 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  R8507_RS08420 (PC0094_16740) - 1647503..1648111 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  R8507_RS08425 (PC0094_16750) - 1648142..1648345 (+) 204 WP_000109957.1 CsbD family protein -
  R8507_RS08430 (PC0094_16760) - 1648455..1648694 (-) 240 WP_001005784.1 transposase -
  R8507_RS08435 (PC0094_16770) - 1648767..1649213 (-) 447 WP_044812424.1 GNAT family N-acetyltransferase -
  R8507_RS08440 (PC0094_16780) cclA/cilC 1649283..1649942 (+) 660 WP_000565001.1 A24 family peptidase Machinery gene
  R8507_RS08445 (PC0094_16790) - 1649994..1651145 (-) 1152 WP_000481750.1 ImmA/IrrE family metallo-endopeptidase -
  R8507_RS08450 (PC0094_16800) - 1651160..1651891 (-) 732 WP_000934017.1 hypothetical protein -
  R8507_RS08455 - 1652117..1652221 (+) 105 Protein_1674 prepilin peptidase -
  R8507_RS08460 (PC0094_16810) trpA 1652193..1652969 (-) 777 WP_001127010.1 tryptophan synthase subunit alpha -
  R8507_RS08465 (PC0094_16820) trpB 1652962..1654185 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  R8507_RS08470 (PC0094_16830) - 1654163..1654762 (-) 600 WP_317643127.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24820.92 Da        Isoelectric Point: 7.2761

>NTDB_id=98359 R8507_RS08440 WP_000565001.1 1649283..1649942(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700097]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=98359 R8507_RS08440 WP_000565001.1 1649283..1649942(+) (cclA/cilC) [Streptococcus pneumoniae strain PZ900700097]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M7B9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

98.174

100

0.982
  cclA/cilC Streptococcus pneumoniae Rx1

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae D39

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae R6

96.804

100

0.968
  cclA/cilC Streptococcus mitis SK321

92.237

100

0.922
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment