Detailed information NTG0098178

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: R8625_RS03740
• Genome accession: NZ_AP026923
• Coordinates: 734976..737234 (-)
• Length: 752 a.a.
• NCBI ID: WP_317649363.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700054
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	733922..734251	734976..737234	flank	725

Gene organization within MGE regions

Location: 733922..737234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8625_RS03735	-	733922..734771 (+)	850	Protein_740	IS630 family transposase	-
R8625_RS03740 (PC0054_07400)	clpE	734976..737234 (-)	2259	WP_317649363.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83794.33 Da
• Isoelectric Point: 5.5494

>NTDB_id=98178 R8625_RS03740 WP_317649363.1 734976..737234(-) (clpE) [Streptococcus pneumoniae strain PZ900700054]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLKEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKSLSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGKIQIKSAKKAEVKTSEKEV

Nucleotide

• Length: 2259 bp

>NTDB_id=98178 R8625_RS03740 WP_317649363.1 734976..737234(-) (clpE) [Streptococcus pneumoniae strain PZ900700054]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGAAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTAGATGAACCAACGG
TGGATGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACCGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAAGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATTGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GACAAGATGATGCTGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGTCTCGGTACACCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTCGGACCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCTATCGAACTCTTTGGTTC
TGCTGACAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGACAATTAACTGAAAAAGTTCGCCGCAATCCATATTCTCTTATTCTCTTGGATGAA
GTAGAAAAAGCCCATCCAGATGTCATGCACATGTTCCTCCAGGTCTTGGACGATGGTCGTTTGACAGATGGGCAAGGACG
TACCGTCAGCTTCAAGGATGCCATTATTATCATGACTTCAAATGCAGGGACAGGTAAGGCTGAAGCCAGCGTTGGTTTTG
GGGCTGCTCGCGAAGGACGTACCAACTCTGTTCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGTCTCTCAGCAAAGATAACCTCCTTCAGATTGTCGAGCTTATGCTAGCAGACGTTAACAA
GCGCCTTTCTAGCAACAACATTCATTTGGATGTAACTGACAAGGTCAAGGAAAAATTGGTTGACCTCGGTTATGATCCAA
AAATGGGGGCGCGCCCACTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGACCTCAAGGCAGTTATGACCAGCAAGGGTAAGATTCAAATTAAGTCTGCCAAAAAAGCTGAAGTTAAAAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (293-390)

• ATPase family associated with various cellular activities (AAA) (AAA) (155-276)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (649-723)

• AAA domain (Cdc48 subfamily) (AAA_2) (478-641)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	98.935	99.867	0.988
clpE	Streptococcus pneumoniae D39	98.935	99.867	0.988
clpE	Streptococcus pneumoniae R6	98.935	99.867	0.988
clpE	Streptococcus pneumoniae TIGR4	98.802	99.867	0.987
clpE	Streptococcus mutans UA159	82.8	99.734	0.826
clpC	Lactococcus lactis subsp. cremoris KW2	75.099	100	0.758
clpC	Bacillus subtilis subsp. subtilis str. 168	51.331	89.894	0.461
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.309	82.58	0.399
clpC	Streptococcus pneumoniae Rx1	46.91	83.91	0.394
clpC	Streptococcus pneumoniae D39	46.91	83.91	0.394
clpC	Streptococcus pneumoniae TIGR4	46.91	83.91	0.394
clpC	Streptococcus thermophilus LMD-9	46.955	82.979	0.39
clpC	Streptococcus mutans UA159	46.571	83.378	0.388
clpC	Streptococcus thermophilus LMG 18311	46.56	83.112	0.387