Detailed information NTG0098095

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8586_RS02570
• Genome accession: NZ_AP026922
• Coordinates: 499106..499693 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700038
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 494106..504693

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8586_RS02550 (PC0038_05000)	-	494556..495896 (+)	1341	WP_001099892.1	sensor histidine kinase	-
R8586_RS02555 (PC0038_05010)	blpC	495940..496095 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
R8586_RS02560 (PC0038_05020)	-	496152..497513 (-)	1362	WP_001069071.1	bacteriocin secretion accessory protein	-
R8586_RS02565 (PC0038_05030)	comA/nlmT	497524..499014 (-)	1491	WP_001818755.1	peptide cleavage/export ABC transporter	Regulator
R8586_RS02570 (PC0038_05040)	comA/nlmT	499106..499693 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8586_RS02575 (PC0038_05050)	blpI	499975..500172 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R8586_RS02580 (PC0038_05070)	blpJ	500639..500908 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
R8586_RS02585 (PC0038_05080)	blpU	500977..501207 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
R8586_RS02590	-	501210..501329 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R8586_RS02595 (PC0038_05100)	-	502115..502499 (+)	385	Protein_510	immunity protein	-
R8586_RS02600 (PC0038_05110)	-	502551..503240 (+)	690	WP_000760515.1	CPBP family intramembrane glutamic endopeptidase	-
R8586_RS02605 (PC0038_05120)	blpZ	503282..503530 (+)	249	WP_000276500.1	immunity protein BlpZ	-
R8586_RS02610	-	503560..504171 (+)	612	WP_000394044.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=98095 R8586_RS02570 WP_000205166.1 499106..499693(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700038]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=98095 R8586_RS02570 WP_000205166.1 499106..499693(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700038]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497