Detailed information NTG0098093

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8586_RS02545
• Genome accession: NZ_AP026922
• Coordinates: 493805..494542 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219141.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700038
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 488805..499542

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8586_RS02510 (PC0038_04920)	-	489735..489974 (-)	240	WP_001813906.1	hypothetical protein	-
R8586_RS02515 (PC0038_04930)	-	490136..490423 (-)	288	WP_000777753.1	hypothetical protein	-
R8586_RS02520 (PC0038_04940)	-	490433..490843 (-)	411	WP_001278304.1	HIT family protein	-
R8586_RS02525 (PC0038_04950)	pptA	490911..491642 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
R8586_RS02530 (PC0038_04960)	-	491639..492688 (+)	1050	WP_000653751.1	ABC transporter permease	-
R8586_RS02535 (PC0038_04970)	-	492856..493185 (-)	330	WP_000132572.1	hypothetical protein	-
R8586_RS02540 (PC0038_04980)	-	493462..493800 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
R8586_RS02545 (PC0038_04990)	comE/blpR	493805..494542 (+)	738	WP_001219141.1	response regulator transcription factor	Regulator
R8586_RS02550 (PC0038_05000)	-	494556..495896 (+)	1341	WP_001099892.1	sensor histidine kinase	-
R8586_RS02555 (PC0038_05010)	blpC	495940..496095 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
R8586_RS02560 (PC0038_05020)	-	496152..497513 (-)	1362	WP_001069071.1	bacteriocin secretion accessory protein	-
R8586_RS02565 (PC0038_05030)	comA/nlmT	497524..499014 (-)	1491	WP_001818755.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.87 Da
• Isoelectric Point: 6.2366

>NTDB_id=98093 R8586_RS02545 WP_001219141.1 493805..494542(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700038]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=98093 R8586_RS02545 WP_001219141.1 493805..494542(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700038]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.441	100	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38