Detailed information NTG0978614

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS37637_RS06395
• Genome accession: NZ_CP151470
• Coordinates: 1244061..1245098 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS37637
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1239061..1250098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37637_RS06375 (MGAS37637_02616)	-	1239812..1240438 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS37637_RS06380 (MGAS37637_02618)	rlmN	1240520..1241599 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS37637_RS06385 (MGAS37637_02620)	-	1241603..1242223 (-)	621	WP_011285637.1	YutD family protein	-
MGAS37637_RS06390 (MGAS37637_02622)	-	1242671..1243647 (-)	977	Protein_1213	LacI family DNA-binding transcriptional regulator	-
MGAS37637_RS06395 (MGAS37637_02626)	sepM	1244061..1245098 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS37637_RS06400 (MGAS37637_02628)	coaD	1245085..1245576 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS37637_RS06405 (MGAS37637_02630)	rsmD	1245566..1246105 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS37637_RS06410 (MGAS37637_02632)	asnA	1246228..1247220 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS37637_RS06415 (MGAS37637_02634)	arcC	1247533..1248483 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS37637_RS06420 (MGAS37637_02636)	-	1248503..1249834 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=978614 MGAS37637_RS06395 WP_010922499.1 1244061..1245098(-) (sepM) [Streptococcus pyogenes strain MGAS37637]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=978614 MGAS37637_RS06395 WP_010922499.1 1244061..1245098(-) (sepM) [Streptococcus pyogenes strain MGAS37637]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693