Detailed information NTG0978469

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS37642_RS00405
• Genome accession: NZ_CP151468
• Coordinates: 59325..60236 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS37642
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 54325..65236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37642_RS00385 (MGAS37642_00152)	purE	54662..55153 (+)	492	WP_015055884.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS37642_RS00390 (MGAS37642_00154)	purK	55140..56213 (+)	1074	WP_015055885.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS37642_RS00395 (MGAS37642_00156)	-	56240..57883 (+)	1644	WP_010921779.1	AIPR family protein	-
MGAS37642_RS00400 (MGAS37642_00158)	purB	57901..59193 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
MGAS37642_RS00405 (MGAS37642_00160)	comR	59325..60236 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS37642_RS00410 (MGAS37642_00162)	comS	60320..60415 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS37642_RS00415 (MGAS37642_00164)	ruvB	60462..61460 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS37642_RS00420 (MGAS37642_00166)	-	61598..62035 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS37642_RS00425 (MGAS37642_00168)	-	62058..62459 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
MGAS37642_RS00430 (MGAS37642_00170)	-	62456..64231 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=978469 MGAS37642_RS00405 WP_002986681.1 59325..60236(+) (comR) [Streptococcus pyogenes strain MGAS37642]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=978469 MGAS37642_RS00405 WP_002986681.1 59325..60236(+) (comR) [Streptococcus pyogenes strain MGAS37642]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462