Detailed information NTG0977943

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS37832_RS06420
• Genome accession: NZ_CP151458
• Coordinates: 1248321..1249358 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS37832
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1243321..1254358

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37832_RS06400 (MGAS37832_02630)	-	1244072..1244698 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS37832_RS06405 (MGAS37832_02632)	rlmN	1244780..1245859 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS37832_RS06410 (MGAS37832_02634)	-	1245863..1246483 (-)	621	WP_011285637.1	YutD family protein	-
MGAS37832_RS06415 (MGAS37832_02636)	-	1246931..1247907 (-)	977	Protein_1215	LacI family DNA-binding transcriptional regulator	-
MGAS37832_RS06420 (MGAS37832_02640)	sepM	1248321..1249358 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS37832_RS06425 (MGAS37832_02642)	coaD	1249345..1249836 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS37832_RS06430 (MGAS37832_02644)	rsmD	1249826..1250365 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS37832_RS06435 (MGAS37832_02646)	asnA	1250488..1251480 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS37832_RS06440 (MGAS37832_02648)	arcC	1251793..1252743 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS37832_RS06445 (MGAS37832_02650)	-	1252763..1254094 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=977943 MGAS37832_RS06420 WP_010922499.1 1248321..1249358(-) (sepM) [Streptococcus pyogenes strain MGAS37832]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=977943 MGAS37832_RS06420 WP_010922499.1 1248321..1249358(-) (sepM) [Streptococcus pyogenes strain MGAS37832]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693