Detailed information NTG0977495

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS37844_RS06395
• Genome accession: NZ_CP151450
• Coordinates: 1244093..1245130 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS37844
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1239093..1250130

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37844_RS06375 (MGAS37844_02618)	-	1239844..1240470 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS37844_RS06380 (MGAS37844_02620)	rlmN	1240552..1241631 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS37844_RS06385 (MGAS37844_02622)	-	1241635..1242255 (-)	621	WP_011285637.1	YutD family protein	-
MGAS37844_RS06390 (MGAS37844_02624)	-	1242703..1243679 (-)	977	Protein_1213	LacI family DNA-binding transcriptional regulator	-
MGAS37844_RS06395 (MGAS37844_02628)	sepM	1244093..1245130 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS37844_RS06400 (MGAS37844_02630)	coaD	1245117..1245608 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS37844_RS06405 (MGAS37844_02632)	rsmD	1245598..1246137 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS37844_RS06410 (MGAS37844_02634)	asnA	1246260..1247252 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS37844_RS06415 (MGAS37844_02636)	arcC	1247565..1248515 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS37844_RS06420 (MGAS37844_02638)	-	1248535..1249866 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=977495 MGAS37844_RS06395 WP_010922499.1 1244093..1245130(-) (sepM) [Streptococcus pyogenes strain MGAS37844]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=977495 MGAS37844_RS06395 WP_010922499.1 1244093..1245130(-) (sepM) [Streptococcus pyogenes strain MGAS37844]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693