Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MGAS37844_RS04840 Genome accession   NZ_CP151450
Coordinates   961186..961860 (-) Length   224 a.a.
NCBI ID   WP_010922355.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS37844     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 956186..966860
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS37844_RS04815 (MGAS37844_01986) - 956633..957022 (-) 390 WP_011285547.1 cytidine deaminase -
  MGAS37844_RS04820 (MGAS37844_01988) - 957681..958268 (-) 588 WP_011285548.1 class I SAM-dependent methyltransferase -
  MGAS37844_RS04825 (MGAS37844_01990) coaA 958536..959456 (+) 921 WP_010922353.1 type I pantothenate kinase -
  MGAS37844_RS04830 (MGAS37844_01992) rpsT 959510..959758 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  MGAS37844_RS04835 (MGAS37844_01994) ciaH 959883..961193 (-) 1311 WP_010922354.1 cell wall metabolism sensor histidine kinase WalK Regulator
  MGAS37844_RS04840 (MGAS37844_01996) ciaR 961186..961860 (-) 675 WP_010922355.1 response regulator transcription factor Regulator
  MGAS37844_RS04845 (MGAS37844_01998) - 962206..964743 (-) 2538 WP_010922356.1 M1 family metallopeptidase -
  MGAS37844_RS04850 (MGAS37844_02000) phoU 964948..965601 (-) 654 WP_027969197.1 phosphate signaling complex protein PhoU -
  MGAS37844_RS04855 (MGAS37844_02002) pstB 965669..966427 (-) 759 WP_076640023.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25650.86 Da        Isoelectric Point: 4.6480

>NTDB_id=977488 MGAS37844_RS04840 WP_010922355.1 961186..961860(-) (ciaR) [Streptococcus pyogenes strain MGAS37844]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=977488 MGAS37844_RS04840 WP_010922355.1 961186..961860(-) (ciaR) [Streptococcus pyogenes strain MGAS37844]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCTGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment