Detailed information NTG0976935

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS38289_RS06335
• Genome accession: NZ_CP151440
• Coordinates: 1238061..1239098 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS38289
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1233061..1244098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS38289_RS06315 (MGAS38289_02588)	-	1233812..1234438 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS38289_RS06320 (MGAS38289_02590)	rlmN	1234520..1235599 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS38289_RS06325 (MGAS38289_02592)	-	1235603..1236223 (-)	621	WP_011285637.1	YutD family protein	-
MGAS38289_RS06330 (MGAS38289_02594)	-	1236671..1237647 (-)	977	Protein_1214	LacI family DNA-binding transcriptional regulator	-
MGAS38289_RS06335 (MGAS38289_02598)	sepM	1238061..1239098 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS38289_RS06340 (MGAS38289_02600)	coaD	1239085..1239576 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS38289_RS06345 (MGAS38289_02602)	rsmD	1239566..1240105 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS38289_RS06350 (MGAS38289_02604)	asnA	1240228..1241220 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS38289_RS06355 (MGAS38289_02606)	arcC	1241533..1242483 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS38289_RS06360 (MGAS38289_02608)	-	1242503..1243834 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=976935 MGAS38289_RS06335 WP_010922499.1 1238061..1239098(-) (sepM) [Streptococcus pyogenes strain MGAS38289]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=976935 MGAS38289_RS06335 WP_010922499.1 1238061..1239098(-) (sepM) [Streptococcus pyogenes strain MGAS38289]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693