Detailed information NTG0976902

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS38289_RS00275
• Genome accession: NZ_CP151440
• Coordinates: 47323..48234 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS38289
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42323..53234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS38289_RS00255 (MGAS38289_00100)	purE	42660..43151 (+)	492	WP_015055884.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS38289_RS00260 (MGAS38289_00102)	purK	43138..44211 (+)	1074	WP_015055885.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS38289_RS00265 (MGAS38289_00104)	-	44238..45881 (+)	1644	WP_010921779.1	AIPR family protein	-
MGAS38289_RS00270 (MGAS38289_00106)	purB	45899..47191 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
MGAS38289_RS00275 (MGAS38289_00108)	comR	47323..48234 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS38289_RS00280 (MGAS38289_00110)	comS	48318..48413 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS38289_RS00285 (MGAS38289_00112)	ruvB	48460..49458 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS38289_RS00290 (MGAS38289_00114)	-	49596..50033 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS38289_RS00295 (MGAS38289_00116)	-	50056..50457 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
MGAS38289_RS00300 (MGAS38289_00118)	-	50454..52229 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=976902 MGAS38289_RS00275 WP_002986681.1 47323..48234(+) (comR) [Streptococcus pyogenes strain MGAS38289]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=976902 MGAS38289_RS00275 WP_002986681.1 47323..48234(+) (comR) [Streptococcus pyogenes strain MGAS38289]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462