Detailed information NTG0976823

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS38343_RS06415
• Genome accession: NZ_CP151438
• Coordinates: 1244373..1245410 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain MGAS38343
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1239373..1250410

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS38343_RS06395 (MGAS38343_02618)	-	1240124..1240750 (+)	627	WP_010922497.1	A24 family peptidase	-
MGAS38343_RS06400 (MGAS38343_02620)	rlmN	1240832..1241911 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS38343_RS06405 (MGAS38343_02622)	-	1241915..1242535 (-)	621	WP_011285637.1	YutD family protein	-
MGAS38343_RS06410 (MGAS38343_02624)	-	1242983..1243959 (-)	977	Protein_1214	LacI family DNA-binding transcriptional regulator	-
MGAS38343_RS06415 (MGAS38343_02628)	sepM	1244373..1245410 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
MGAS38343_RS06420 (MGAS38343_02630)	coaD	1245397..1245888 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS38343_RS06425 (MGAS38343_02632)	rsmD	1245878..1246417 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS38343_RS06430 (MGAS38343_02634)	asnA	1246540..1247532 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
MGAS38343_RS06435 (MGAS38343_02636)	arcC	1247845..1248795 (-)	951	WP_010922501.1	carbamate kinase	-
MGAS38343_RS06440 (MGAS38343_02638)	-	1248815..1250146 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=976823 MGAS38343_RS06415 WP_010922499.1 1244373..1245410(-) (sepM) [Streptococcus pyogenes strain MGAS38343]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=976823 MGAS38343_RS06415 WP_010922499.1 1244373..1245410(-) (sepM) [Streptococcus pyogenes strain MGAS38343]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693