Detailed information NTG0976019

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: UXR11_RS10380
• Genome accession: NZ_CP151257
• Coordinates: 2076264..2077307 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN170
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2071264..2082307

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UXR11_RS10350 (UXR11_10350)	-	2071685..2072941 (-)	1257	WP_001795108.1	aminopeptidase	-
UXR11_RS10355 (UXR11_10355)	-	2072944..2073144 (-)	201	WP_000180460.1	DUF1128 family protein	-
UXR11_RS10360 (UXR11_10360)	-	2073291..2073755 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
UXR11_RS10365 (UXR11_10365)	-	2073762..2074037 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
UXR11_RS10370 (UXR11_10370)	-	2074315..2075532 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
UXR11_RS10375 (UXR11_10375)	vraR	2075645..2076274 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
UXR11_RS10380 (UXR11_10380)	vraS	2076264..2077307 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
UXR11_RS10385 (UXR11_10385)	liaF	2077304..2078005 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
UXR11_RS10390 (UXR11_10390)	-	2078020..2078406 (-)	387	WP_001110179.1	hypothetical protein	-
UXR11_RS10395 (UXR11_10395)	map	2078623..2079381 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
UXR11_RS10400 (UXR11_10400)	-	2079853..2080839 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
UXR11_RS10405 (UXR11_10405)	-	2081270..2081683 (-)	414	WP_001557448.1	hypothetical protein	-
UXR11_RS10410 (UXR11_10410)	-	2081712..2081822 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=976019 UXR11_RS10380 WP_001017131.1 2076264..2077307(-) (vraS) [Staphylococcus aureus strain BSN170]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=976019 UXR11_RS10380 WP_001017131.1 2076264..2077307(-) (vraS) [Staphylococcus aureus strain BSN170]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1