Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   R8474_RS06460 Genome accession   NZ_AP026914
Coordinates   1274891..1276225 (-) Length   444 a.a.
NCBI ID   WP_000491790.1    Uniprot ID   Q7B3G0
Organism   Streptococcus pneumoniae strain PZ900700003     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1269891..1281225
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8474_RS06445 (PC0003_12810) - 1270851..1273301 (-) 2451 WP_000848720.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  R8474_RS06450 (PC0003_12820) - 1273501..1274430 (-) 930 WP_000411853.1 peptidase U32 family protein -
  R8474_RS06455 (PC0003_12830) - 1274570..1274857 (+) 288 WP_001145225.1 DUF3270 domain-containing protein -
  R8474_RS06460 (PC0003_12840) ciaH 1274891..1276225 (-) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  R8474_RS06465 (PC0003_12850) ciaR 1276215..1276889 (-) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  R8474_RS06470 (PC0003_12860) - 1276998..1279544 (-) 2547 WP_001149118.1 M1 family metallopeptidase -
  R8474_RS06475 (PC0003_12870) - 1279667..1280107 (-) 441 WP_001820631.1 ASCH domain-containing protein -
  R8474_RS06480 (PC0003_12880) - 1280082..1280951 (-) 870 WP_001245818.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50673.39 Da        Isoelectric Point: 9.1661

>NTDB_id=97490 R8474_RS06460 WP_000491790.1 1274891..1276225(-) (ciaH) [Streptococcus pneumoniae strain PZ900700003]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=97490 R8474_RS06460 WP_000491790.1 1274891..1276225(-) (ciaH) [Streptococcus pneumoniae strain PZ900700003]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCTTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q7B3G0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

100

100

1
  ciaH Streptococcus pneumoniae D39

100

100

1
  ciaH Streptococcus pneumoniae R6

100

100

1
  ciaH Streptococcus pneumoniae TIGR4

100

100

1
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment