Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R8474_RS03925 Genome accession   NZ_AP026914
Coordinates   765093..765830 (+) Length   245 a.a.
NCBI ID   WP_000782665.1    Uniprot ID   A0A0B7LV94
Organism   Streptococcus pneumoniae strain PZ900700003     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 760093..770830
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8474_RS03905 (PC0003_07730) - 760344..761447 (+) 1104 WP_000225894.1 glycosyltransferase -
  R8474_RS03910 (PC0003_07740) - 761449..762435 (+) 987 WP_000446980.1 glycosyltransferase family 2 protein -
  R8474_RS03915 (PC0003_07750) - 762451..763884 (+) 1434 WP_000565096.1 O-antigen polysaccharide polymerase Wzy family protein -
  R8474_RS03920 (PC0003_07760) - 763913..764947 (+) 1035 WP_000461502.1 hypothetical protein -
  R8474_RS03925 (PC0003_07770) mecA 765093..765830 (+) 738 WP_000782665.1 adaptor protein MecA Regulator
  R8474_RS03930 (PC0003_07780) - 765981..767267 (+) 1287 WP_000216383.1 homoserine dehydrogenase -
  R8474_RS03935 (PC0003_07790) thrB 767269..768138 (+) 870 WP_000692438.1 homoserine kinase -
  R8474_RS03940 (PC0003_07800) - 768214..768450 (+) 237 WP_001820728.1 hypothetical protein -
  R8474_RS03945 (PC0003_07810) msrB 768479..769417 (+) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28377.18 Da        Isoelectric Point: 4.0236

>NTDB_id=97480 R8474_RS03925 WP_000782665.1 765093..765830(+) (mecA) [Streptococcus pneumoniae strain PZ900700003]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=97480 R8474_RS03925 WP_000782665.1 765093..765830(+) (mecA) [Streptococcus pneumoniae strain PZ900700003]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LV94

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment