Detailed information NTG0972654

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC64_RS06360
• Genome accession: NZ_CP150788
• Coordinates: 1277172..1278215 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20816
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1272172..1283215

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC64_RS06330 (WOC64_06335)	-	1272542..1272652 (+)	111	WP_001790257.1	hypothetical protein	-
WOC64_RS06335 (WOC64_06340)	-	1272681..1273094 (+)	414	WP_001549145.1	hypothetical protein	-
WOC64_RS06340 (WOC64_06345)	-	1273525..1274511 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC64_RS06345 (WOC64_06350)	map	1275098..1275856 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC64_RS06350 (WOC64_06355)	-	1276073..1276459 (+)	387	WP_001110179.1	hypothetical protein	-
WOC64_RS06355 (WOC64_06360)	liaF	1276474..1277175 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC64_RS06360 (WOC64_06365)	vraS	1277172..1278215 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC64_RS06365 (WOC64_06370)	vraR	1278205..1278834 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
WOC64_RS06370 (WOC64_06375)	-	1278950..1280167 (-)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
WOC64_RS06375 (WOC64_06380)	-	1280445..1280720 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC64_RS06380 (WOC64_06385)	-	1280727..1281191 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC64_RS06385 (WOC64_06390)	-	1281338..1281538 (+)	201	WP_000180461.1	DUF1128 family protein	-
WOC64_RS06390 (WOC64_06395)	-	1281541..1282797 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972654 WOC64_RS06360 WP_001017131.1 1277172..1278215(+) (vraS) [Staphylococcus aureus strain TUM20816]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972654 WOC64_RS06360 WP_001017131.1 1277172..1278215(+) (vraS) [Staphylococcus aureus strain TUM20816]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1