Detailed information NTG0972459

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC48_RS12910
• Genome accession: NZ_CP150777
• Coordinates: 2600555..2601598 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20825
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2595555..2606598

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC48_RS12880 (WOC48_12865)	-	2595921..2596032 (+)	112	Protein_2532	hypothetical protein	-
WOC48_RS12885 (WOC48_12870)	-	2596061..2596474 (+)	414	WP_001837236.1	hypothetical protein	-
WOC48_RS12890 (WOC48_12875)	-	2596964..2597950 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC48_RS12895 (WOC48_12880)	map	2598481..2599239 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC48_RS12900 (WOC48_12885)	-	2599456..2599842 (+)	387	WP_001110179.1	hypothetical protein	-
WOC48_RS12905 (WOC48_12890)	liaF	2599857..2600558 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC48_RS12910 (WOC48_12895)	vraS	2600555..2601598 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC48_RS12915 (WOC48_12900)	vraR	2601588..2602217 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC48_RS12920 (WOC48_12905)	-	2602329..2603540 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
WOC48_RS12925 (WOC48_12910)	-	2603818..2604093 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC48_RS12930 (WOC48_12915)	-	2604100..2604564 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC48_RS12935 (WOC48_12920)	-	2604711..2604911 (+)	201	WP_000180460.1	DUF1128 family protein	-
WOC48_RS12940 (WOC48_12925)	-	2604914..2606170 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972459 WOC48_RS12910 WP_001017131.1 2600555..2601598(+) (vraS) [Staphylococcus aureus strain TUM20825]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972459 WOC48_RS12910 WP_001017131.1 2600555..2601598(+) (vraS) [Staphylococcus aureus strain TUM20825]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1