Detailed information NTG0972401

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC57_RS10955
• Genome accession: NZ_CP150775
• Coordinates: 2187200..2188243 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20888
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2182200..2193243

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC57_RS10925 (WOC57_10935)	-	2182629..2182739 (+)	111	WP_001790257.1	hypothetical protein	-
WOC57_RS10930 (WOC57_10940)	-	2182768..2183181 (+)	414	WP_001549145.1	hypothetical protein	-
WOC57_RS10935 (WOC57_10945)	-	2183612..2184598 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC57_RS10940 (WOC57_10950)	map	2185126..2185884 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC57_RS10945 (WOC57_10955)	-	2186101..2186487 (+)	387	WP_001110179.1	hypothetical protein	-
WOC57_RS10950 (WOC57_10960)	liaF	2186502..2187203 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC57_RS10955 (WOC57_10965)	vraS	2187200..2188243 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC57_RS10960 (WOC57_10970)	vraR	2188233..2188862 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
WOC57_RS10965 (WOC57_10975)	-	2188978..2190195 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
WOC57_RS10970 (WOC57_10980)	-	2190473..2190748 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC57_RS10975 (WOC57_10985)	-	2190755..2191219 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC57_RS10980 (WOC57_10990)	-	2191366..2191566 (+)	201	WP_000180461.1	DUF1128 family protein	-
WOC57_RS10985 (WOC57_10995)	-	2191569..2192825 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=972401 WOC57_RS10955 WP_001017131.1 2187200..2188243(+) (vraS) [Staphylococcus aureus strain TUM20888]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=972401 WOC57_RS10955 WP_001017131.1 2187200..2188243(+) (vraS) [Staphylococcus aureus strain TUM20888]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1