Detailed information NTG0971911

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC65_RS05275
• Genome accession: NZ_CP150756
• Coordinates: 1070758..1071801 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22188
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1065758..1076801

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC65_RS05245 (WOC65_05240)	-	1066124..1066235 (+)	112	Protein_1032	hypothetical protein	-
WOC65_RS05250 (WOC65_05245)	-	1066264..1066677 (+)	414	WP_001837236.1	hypothetical protein	-
WOC65_RS05255 (WOC65_05250)	-	1067167..1068153 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC65_RS05260 (WOC65_05255)	map	1068684..1069442 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC65_RS05265 (WOC65_05260)	-	1069659..1070045 (+)	387	WP_001110179.1	hypothetical protein	-
WOC65_RS05270 (WOC65_05265)	liaF	1070060..1070761 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC65_RS05275 (WOC65_05270)	vraS	1070758..1071801 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC65_RS05280 (WOC65_05275)	vraR	1071791..1072420 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC65_RS05285 (WOC65_05280)	-	1072532..1073743 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
WOC65_RS05290 (WOC65_05285)	-	1074021..1074296 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC65_RS05295 (WOC65_05290)	-	1074303..1074767 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC65_RS05300 (WOC65_05295)	-	1074914..1075114 (+)	201	WP_000180460.1	DUF1128 family protein	-
WOC65_RS05305 (WOC65_05300)	-	1075117..1076373 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971911 WOC65_RS05275 WP_001017131.1 1070758..1071801(+) (vraS) [Staphylococcus aureus strain TUM22188]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971911 WOC65_RS05275 WP_001017131.1 1070758..1071801(+) (vraS) [Staphylococcus aureus strain TUM22188]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1