Detailed information NTG0971850

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC45_RS13360
• Genome accession: NZ_CP150752
• Coordinates: 2665375..2666418 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22458
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2660375..2671418

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC45_RS13330 (WOC45_13330)	-	2660801..2660911 (+)	111	WP_001790257.1	hypothetical protein	-
WOC45_RS13335 (WOC45_13335)	-	2660940..2661353 (+)	414	WP_001557448.1	hypothetical protein	-
WOC45_RS13340 (WOC45_13340)	-	2661784..2662770 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
WOC45_RS13345 (WOC45_13345)	map	2663301..2664059 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC45_RS13350 (WOC45_13350)	-	2664276..2664662 (+)	387	WP_001110179.1	hypothetical protein	-
WOC45_RS13355 (WOC45_13355)	liaF	2664677..2665378 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC45_RS13360 (WOC45_13360)	vraS	2665375..2666418 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC45_RS13365 (WOC45_13365)	vraR	2666408..2667037 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC45_RS13370 (WOC45_13370)	-	2667150..2668367 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
WOC45_RS13375 (WOC45_13375)	-	2668645..2668920 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC45_RS13380 (WOC45_13380)	-	2668927..2669391 (-)	465	WP_042109418.1	low molecular weight protein-tyrosine-phosphatase	-
WOC45_RS13385 (WOC45_13385)	-	2669538..2669738 (+)	201	WP_000180460.1	DUF1128 family protein	-
WOC45_RS13390 (WOC45_13390)	-	2669741..2670997 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971850 WOC45_RS13360 WP_001017131.1 2665375..2666418(+) (vraS) [Staphylococcus aureus strain TUM22458]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971850 WOC45_RS13360 WP_001017131.1 2665375..2666418(+) (vraS) [Staphylococcus aureus strain TUM22458]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1