Detailed information NTG0971706

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC54_RS09950
• Genome accession: NZ_CP150747
• Coordinates: 1991954..1992997 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22701
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1986954..1997997

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC54_RS09920 (WOC54_09945)	-	1987380..1987490 (+)	111	WP_001790257.1	hypothetical protein	-
WOC54_RS09925 (WOC54_09950)	-	1987519..1987932 (+)	414	WP_001557448.1	hypothetical protein	-
WOC54_RS09930 (WOC54_09955)	-	1988363..1989349 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
WOC54_RS09935 (WOC54_09960)	map	1989880..1990638 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC54_RS09940 (WOC54_09965)	-	1990855..1991241 (+)	387	WP_001110179.1	hypothetical protein	-
WOC54_RS09945 (WOC54_09970)	liaF	1991256..1991957 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC54_RS09950 (WOC54_09975)	vraS	1991954..1992997 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC54_RS09955 (WOC54_09980)	vraR	1992987..1993616 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC54_RS09960 (WOC54_09985)	-	1993729..1994946 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
WOC54_RS09965 (WOC54_09990)	-	1995224..1995499 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC54_RS09970 (WOC54_09995)	-	1995506..1995970 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC54_RS09975 (WOC54_10000)	-	1996117..1996317 (+)	201	WP_000180460.1	DUF1128 family protein	-
WOC54_RS09980 (WOC54_10005)	-	1996320..1997576 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971706 WOC54_RS09950 WP_001017131.1 1991954..1992997(+) (vraS) [Staphylococcus aureus strain TUM22701]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971706 WOC54_RS09950 WP_001017131.1 1991954..1992997(+) (vraS) [Staphylococcus aureus strain TUM22701]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1