Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | WOC54_RS05115 | Genome accession | NZ_CP150747 |
| Coordinates | 1050432..1051781 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain TUM22701 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 1050432..1121813 | 1050432..1051781 | within | 0 |
Gene organization within MGE regions
Location: 1050432..1121813
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WOC54_RS05115 (WOC54_05140) | ccrA | 1050432..1051781 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| WOC54_RS05120 (WOC54_05145) | ccrB | 1051803..1053431 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| WOC54_RS05125 (WOC54_05150) | - | 1053949..1054299 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WOC54_RS05130 (WOC54_05155) | - | 1054386..1054697 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| WOC54_RS05135 (WOC54_05160) | - | 1054715..1055221 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| WOC54_RS05140 (WOC54_05165) | - | 1055242..1055559 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| WOC54_RS05145 (WOC54_05170) | - | 1055678..1056763 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| WOC54_RS05150 (WOC54_05175) | - | 1056760..1058652 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| WOC54_RS05155 (WOC54_05180) | - | 1058659..1059036 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| WOC54_RS05160 (WOC54_05185) | - | 1059187..1059969 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| WOC54_RS05165 (WOC54_05190) | erm(A) | 1060095..1060826 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| WOC54_RS05170 | - | 1060909..1060968 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| WOC54_RS05175 (WOC54_05195) | - | 1061360..1062022 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| WOC54_RS05180 (WOC54_05200) | - | 1062367..1063005 (-) | 639 | Protein_1014 | sulfite exporter TauE/SafE family protein | - |
| WOC54_RS05185 (WOC54_05205) | cstR | 1063005..1063265 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| WOC54_RS05190 (WOC54_05210) | - | 1063401..1064465 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| WOC54_RS05195 (WOC54_05215) | cstB | 1064498..1065832 (+) | 1335 | Protein_1017 | persulfide dioxygenase-sulfurtransferase CstB | - |
| WOC54_RS05200 (WOC54_05220) | - | 1065946..1067076 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| WOC54_RS05205 (WOC54_05225) | psm-mec | 1067410..1067478 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| WOC54_RS05210 (WOC54_05230) | mecI | 1067563..1067934 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| WOC54_RS05215 (WOC54_05235) | mecR1 | 1067934..1069691 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| WOC54_RS05220 (WOC54_05240) | mecA | 1069788..1071797 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| WOC54_RS05225 (WOC54_05245) | - | 1071843..1072271 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| WOC54_RS05230 (WOC54_05250) | - | 1072368..1073111 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| WOC54_RS05235 (WOC54_05255) | - | 1073948..1074337 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| WOC54_RS05240 (WOC54_05260) | - | 1074373..1075047 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| WOC54_RS05245 (WOC54_05265) | hutH | 1075167..1076681 (+) | 1515 | WP_000177465.1 | histidine ammonia-lyase | - |
| WOC54_RS05250 (WOC54_05270) | serS | 1077060..1078346 (+) | 1287 | WP_000884332.1 | serine--tRNA ligase | - |
| WOC54_RS05255 (WOC54_05275) | - | 1078997..1079692 (+) | 696 | WP_000190726.1 | AzlC family ABC transporter permease | - |
| WOC54_RS05260 (WOC54_05280) | - | 1079689..1080018 (+) | 330 | WP_000628051.1 | AzlD domain-containing protein | - |
| WOC54_RS05265 (WOC54_05285) | - | 1080381..1081349 (+) | 969 | WP_000186490.1 | alpha/beta fold hydrolase family protein | - |
| WOC54_RS05270 (WOC54_05290) | - | 1081642..1082580 (+) | 939 | WP_341262116.1 | YybS family protein | - |
| WOC54_RS05275 (WOC54_05295) | gdpP | 1082595..1084562 (+) | 1968 | WP_001081640.1 | cyclic-di-AMP phosphodiesterase GdpP | - |
| WOC54_RS05280 (WOC54_05300) | rplI | 1084559..1085005 (+) | 447 | WP_000864305.1 | 50S ribosomal protein L9 | - |
| WOC54_RS05285 (WOC54_05305) | dnaB | 1085037..1086437 (+) | 1401 | WP_000375647.1 | replicative DNA helicase | - |
| WOC54_RS05290 (WOC54_05310) | - | 1086715..1087998 (+) | 1284 | WP_000095328.1 | adenylosuccinate synthase | - |
| WOC54_RS05305 (WOC54_05325) | yycF | 1089201..1089902 (+) | 702 | WP_000101976.1 | response regulator YycF | - |
| WOC54_RS05310 (WOC54_05330) | walK | 1089915..1091741 (+) | 1827 | WP_000871607.1 | cell wall metabolism sensor histidine kinase WalK | - |
| WOC54_RS05315 (WOC54_05335) | yycH | 1091734..1093068 (+) | 1335 | WP_001060140.1 | two-component system activity regulator YycH | - |
| WOC54_RS05320 (WOC54_05340) | - | 1093069..1093857 (+) | 789 | WP_001104165.1 | two-component system regulatory protein YycI | - |
| WOC54_RS05325 (WOC54_05345) | - | 1094246..1095046 (+) | 801 | WP_000088649.1 | MBL fold metallo-hydrolase | - |
| WOC54_RS05330 (WOC54_05350) | adsA | 1095273..1097591 (+) | 2319 | WP_341262117.1 | LPXTG-anchored adenosine synthase AdsA | - |
| WOC54_RS05335 (WOC54_05355) | rlmH | 1097959..1098438 (+) | 480 | WP_000704775.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| WOC54_RS05340 (WOC54_05360) | - | 1098539..1098682 (+) | 144 | WP_001631028.1 | restriction endonuclease subunit R | - |
| WOC54_RS05345 (WOC54_05365) | - | 1098675..1099877 (+) | 1203 | WP_001631029.1 | restriction endonuclease subunit S | - |
| WOC54_RS05350 (WOC54_05370) | - | 1099881..1100141 (-) | 261 | Protein_1046 | IS5/IS1182 family transposase | - |
| WOC54_RS05355 (WOC54_05375) | - | 1100200..1100697 (-) | 498 | WP_001631030.1 | GNAT family N-acetyltransferase | - |
| WOC54_RS05360 (WOC54_05380) | - | 1101369..1101779 (-) | 411 | WP_001631031.1 | DUF2871 domain-containing protein | - |
| WOC54_RS05365 (WOC54_05385) | - | 1101942..1102162 (-) | 221 | Protein_1049 | hypothetical protein | - |
| WOC54_RS05370 (WOC54_05390) | - | 1102177..1102680 (-) | 504 | WP_001631032.1 | DUF1643 domain-containing protein | - |
| WOC54_RS05375 (WOC54_05395) | - | 1102696..1102935 (-) | 240 | Protein_1051 | DUF960 family protein | - |
| WOC54_RS05380 (WOC54_05400) | blaZ | 1103236..1104082 (-) | 847 | Protein_1052 | penicillin-hydrolyzing class A beta-lactamase BlaZ | - |
| WOC54_RS05385 (WOC54_05405) | blaR1 | 1104189..1105946 (+) | 1758 | WP_406822333.1 | beta-lactam sensor/signal transducer BlaR1 | - |
| WOC54_RS05390 (WOC54_05410) | blaI | 1105936..1106316 (+) | 381 | WP_000182645.1 | penicillinase repressor BlaI | - |
| WOC54_RS05395 (WOC54_05415) | - | 1106580..1107173 (+) | 594 | WP_000690638.1 | recombinase family protein | - |
| WOC54_RS05400 (WOC54_05420) | - | 1107145..1108587 (+) | 1443 | WP_002451367.1 | Mu transposase C-terminal domain-containing protein | - |
| WOC54_RS05405 (WOC54_05425) | - | 1108580..1109395 (+) | 816 | WP_000164963.1 | AAA family ATPase | - |
| WOC54_RS05410 (WOC54_05430) | - | 1109481..1109561 (-) | 81 | Protein_1058 | DUF960 family protein | - |
| WOC54_RS05415 (WOC54_05435) | - | 1109648..1109998 (-) | 351 | WP_001631034.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WOC54_RS05420 (WOC54_05440) | ccrB | 1110499..1112127 (-) | 1629 | WP_001631035.1 | cassette chromosome recombinase CcrB | Machinery gene |
| WOC54_RS05425 (WOC54_05445) | ccrA | 1112124..1113485 (-) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| WOC54_RS05430 (WOC54_05450) | - | 1113672..1114301 (-) | 630 | Protein_1062 | hypothetical protein | - |
| WOC54_RS05435 (WOC54_05455) | - | 1114310..1114648 (+) | 339 | Protein_1063 | recombinase family protein | - |
| WOC54_RS05440 (WOC54_05460) | - | 1114760..1115119 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| WOC54_RS05445 (WOC54_05465) | - | 1115326..1115652 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| WOC54_RS05450 (WOC54_05470) | - | 1115982..1116305 (+) | 324 | Protein_1066 | heavy metal translocating P-type ATPase | - |
| WOC54_RS05455 (WOC54_05475) | - | 1116362..1117036 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| WOC54_RS05460 (WOC54_05480) | - | 1117068..1117307 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| WOC54_RS05465 (WOC54_05485) | - | 1117722..1118978 (-) | 1257 | WP_000566670.1 | MrcB family domain-containing protein | - |
| WOC54_RS05470 (WOC54_05490) | - | 1120204..1121811 (-) | 1608 | Protein_1070 | heavy metal translocating P-type ATPase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=971693 WOC54_RS05115 WP_000815646.1 1050432..1051781(+) (ccrA) [Staphylococcus aureus strain TUM22701]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=971693 WOC54_RS05115 WP_000815646.1 1050432..1051781(+) (ccrA) [Staphylococcus aureus strain TUM22701]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAACGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAACGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |