Detailed information NTG0971601

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC66_RS01975
• Genome accession: NZ_CP150743
• Coordinates: 374945..375988 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22705
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 369945..380988

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC66_RS01945 (WOC66_01945)	-	370363..371619 (-)	1257	WP_108932452.1	aminopeptidase	-
WOC66_RS01950 (WOC66_01950)	-	371622..371822 (-)	201	WP_000180461.1	DUF1128 family protein	-
WOC66_RS01955 (WOC66_01955)	-	371969..372433 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC66_RS01960 (WOC66_01960)	-	372440..372715 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC66_RS01965 (WOC66_01965)	-	372993..374210 (+)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
WOC66_RS01970 (WOC66_01970)	vraR	374326..374955 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
WOC66_RS01975 (WOC66_01975)	vraS	374945..375988 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC66_RS01980 (WOC66_01980)	liaF	375985..376686 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC66_RS01985 (WOC66_01985)	-	376701..377087 (-)	387	WP_001110179.1	hypothetical protein	-
WOC66_RS01990 (WOC66_01990)	map	377304..378062 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC66_RS01995 (WOC66_01995)	-	378590..379576 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC66_RS02000 (WOC66_02000)	-	380007..380420 (-)	414	WP_001549145.1	hypothetical protein	-
WOC66_RS02005 (WOC66_02005)	-	380449..380559 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971601 WOC66_RS01975 WP_001017131.1 374945..375988(-) (vraS) [Staphylococcus aureus strain TUM22705]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971601 WOC66_RS01975 WP_001017131.1 374945..375988(-) (vraS) [Staphylococcus aureus strain TUM22705]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1