Detailed information NTG0971336

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WOC72_RS01395
• Genome accession: NZ_CP150731
• Coordinates: 265208..266251 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM22744
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 260208..271251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WOC72_RS01365 (WOC72_01365)	-	260636..261892 (-)	1257	WP_001793428.1	aminopeptidase	-
WOC72_RS01370 (WOC72_01370)	-	261895..262095 (-)	201	WP_000180460.1	DUF1128 family protein	-
WOC72_RS01375 (WOC72_01375)	-	262242..262706 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WOC72_RS01380 (WOC72_01380)	-	262713..262988 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
WOC72_RS01385 (WOC72_01385)	-	263266..264477 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
WOC72_RS01390 (WOC72_01390)	vraR	264589..265218 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
WOC72_RS01395 (WOC72_01395)	vraS	265208..266251 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WOC72_RS01400 (WOC72_01400)	liaF	266248..266949 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WOC72_RS01405 (WOC72_01405)	-	266964..267350 (-)	387	WP_001110179.1	hypothetical protein	-
WOC72_RS01410 (WOC72_01410)	map	267567..268325 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WOC72_RS01415 (WOC72_01415)	-	268856..269842 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
WOC72_RS01420 (WOC72_01420)	-	270332..270745 (-)	414	WP_001837236.1	hypothetical protein	-
WOC72_RS01425 (WOC72_01425)	-	270774..270885 (-)	112	Protein_245	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971336 WOC72_RS01395 WP_001017131.1 265208..266251(-) (vraS) [Staphylococcus aureus strain TUM22744]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971336 WOC72_RS01395 WP_001017131.1 265208..266251(-) (vraS) [Staphylococcus aureus strain TUM22744]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1