Detailed information NTG0971007

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: UXR45_RS08455
• Genome accession: NZ_CP150657
• Coordinates: 1662381..1663424 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN214
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1657381..1668424

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UXR45_RS08425 (UXR45_08425)	-	1657810..1657920 (+)	111	WP_001790257.1	hypothetical protein	-
UXR45_RS08430 (UXR45_08430)	-	1657949..1658362 (+)	414	WP_001549145.1	hypothetical protein	-
UXR45_RS08435 (UXR45_08435)	-	1658793..1659779 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
UXR45_RS08440 (UXR45_08440)	map	1660307..1661065 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
UXR45_RS08445 (UXR45_08445)	-	1661282..1661668 (+)	387	WP_001110179.1	hypothetical protein	-
UXR45_RS08450 (UXR45_08450)	liaF	1661683..1662384 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
UXR45_RS08455 (UXR45_08455)	vraS	1662381..1663424 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
UXR45_RS08460 (UXR45_08460)	vraR	1663414..1664043 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
UXR45_RS08465 (UXR45_08465)	-	1664159..1665376 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
UXR45_RS08470 (UXR45_08470)	-	1665654..1665929 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
UXR45_RS08475 (UXR45_08475)	-	1665936..1666400 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
UXR45_RS08480 (UXR45_08480)	-	1666547..1666747 (+)	201	WP_000180461.1	DUF1128 family protein	-
UXR45_RS08485 (UXR45_08485)	-	1666750..1668006 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=971007 UXR45_RS08455 WP_001017131.1 1662381..1663424(+) (vraS) [Staphylococcus aureus strain BSN214]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=971007 UXR45_RS08455 WP_001017131.1 1662381..1663424(+) (vraS) [Staphylococcus aureus strain BSN214]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1