Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ACJWMC_RS10605 Genome accession   NZ_CP177181
Coordinates   2235942..2237879 (+) Length   645 a.a.
NCBI ID   WP_002889591.1    Uniprot ID   J7TGN8
Organism   Streptococcus salivarius strain MRD1919     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2230942..2242879
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS10575 argR 2231145..2231573 (+) 429 WP_186821380.1 arginine repressor -
  ACJWMC_RS10580 - 2231573..2231932 (+) 360 WP_002889586.1 YlbF family regulator -
  ACJWMC_RS10585 hexA 2231952..2234483 (+) 2532 WP_411893052.1 DNA mismatch repair protein MutS Machinery gene
  ACJWMC_RS10590 - 2234517..2234972 (-) 456 WP_002889588.1 DUF3021 domain-containing protein -
  ACJWMC_RS10595 - 2234969..2235406 (-) 438 WP_002889589.1 LytTR family DNA-binding domain-containing protein -
  ACJWMC_RS10600 - 2235585..2235890 (+) 306 WP_002889590.1 hypothetical protein -
  ACJWMC_RS10605 hexB 2235942..2237879 (+) 1938 WP_002889591.1 DNA mismatch repair endonuclease MutL Machinery gene
  ACJWMC_RS10610 - 2238010..2238231 (+) 222 WP_037597288.1 hypothetical protein -
  ACJWMC_RS10615 - 2238274..2238479 (-) 206 Protein_2039 transposase -
  ACJWMC_RS10620 - 2238533..2238870 (+) 338 Protein_2040 transposase -
  ACJWMC_RS10625 - 2240166..2240210 (+) 45 WP_231606052.1 hypothetical protein -
  ACJWMC_RS10630 - 2240606..2241400 (-) 795 WP_002892250.1 helix-turn-helix domain-containing protein -
  ACJWMC_RS10635 - 2241752..2241940 (+) 189 WP_050989614.1 helix-turn-helix domain-containing protein -
  ACJWMC_RS10640 - 2242008..2242712 (+) 705 WP_037598673.1 hypothetical protein -

Sequence

Protein


Download         Length: 645 a.a.        Molecular weight: 72356.43 Da        Isoelectric Point: 5.2797

>NTDB_id=969776 ACJWMC_RS10605 WP_002889591.1 2235942..2237879(+) (hexB) [Streptococcus salivarius strain MRD1919]
MPKIIELPEVLANQIAAGEVVERPASVVKELVENAIDAGSTQITIEVEESGLSKIQITDNGEGMAQADVAMSLRRHATSK
IKNQGDLFRIRTLGFRGEALPSIASISHLTIVTAADGEAYGTKLVAKGGEIESQDPISTPVGTKITVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLLNDGRQLTQTSGTGDLRQAIAGIYGLTTAKKMVEISNSDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAIFDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMALISS
AIAQSLREQDLIPDALENLAKSSTRGVSKPVQTSLPLKQTNLYYDSSRNDFFVKPETVQEDIKPLVSESPVSSVENKPQP
SVKQAQRSADESDSEHEKLDYKNKSKMKRMLENLDNEETSTFPELEFFGQMHGTYLFAQGQGGLYIIDQHAAQERVKYEY
YREKIGEIDSSLQQLLVPYLFEFSGSDYISLQEKMPLLNQVGIYLEPYGNNTFILREHPIWMKEEEIESAVYEMCDMLLL
TNEVSVKTYRAELAIMMSCKRSIKANHALDDYSARDLLVQLAQCKNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTSLR
DLGKY

Nucleotide


Download         Length: 1938 bp        

>NTDB_id=969776 ACJWMC_RS10605 WP_002889591.1 2235942..2237879(+) (hexB) [Streptococcus salivarius strain MRD1919]
ATGCCAAAAATCATCGAATTGCCTGAAGTTCTAGCCAATCAGATTGCTGCTGGAGAGGTCGTAGAGCGACCAGCTAGTGT
AGTTAAAGAGCTGGTGGAAAATGCTATTGATGCAGGCAGCACCCAGATTACTATTGAAGTTGAAGAATCAGGCCTCTCAA
AAATTCAAATTACAGACAATGGCGAAGGAATGGCTCAAGCTGACGTGGCTATGAGTTTGCGCCGTCATGCAACAAGTAAA
ATCAAAAATCAAGGAGACCTCTTTCGTATTCGAACTCTTGGTTTTCGAGGTGAGGCCCTGCCATCAATAGCTTCTATCAG
TCATCTTACCATTGTGACGGCGGCTGATGGAGAAGCCTATGGGACTAAACTGGTTGCCAAGGGTGGGGAAATTGAGAGTC
AGGATCCTATTTCAACACCAGTTGGAACAAAGATTACCGTTGAAAACTTATTTTATAACACCCCAGCTCGTCTCAAGTAT
ATGAAGAGTTTACAGGCCGAGTTGGCTCATATTGTCGATGTTGTCAATCGTTTGAGTTTAGCCCACCCCGAAGTTGCCTT
CACCTTGCTTAATGACGGTCGTCAGTTGACACAGACCTCAGGTACTGGAGACCTCCGTCAAGCTATTGCCGGGATTTATG
GTTTGACAACGGCTAAAAAAATGGTGGAAATTTCAAATTCTGACCTTGATTTTGAAGTTTCTGGCTATGTTAGTCTCCCT
GAGTTGACCCGTGCGAATCGTAACTACATCACGATTCTCATTAACGGACGTTATATTAAAAACTTCCTGCTTAACCGTGC
TATTTTTGATGGTTATGGTTCTAAACTCATGGTAGGACGCTTCCCTATTGCAGTTATTGATATTCAAATTGATCCCTACC
TGGCCGATGTCAATGTTCACCCAACCAAGCAGGAAGTACGTATCTCTAAAGAAAAAGAGCTCATGGCCCTTATCAGCTCT
GCCATTGCTCAAAGCCTTAGAGAGCAGGATTTGATTCCTGATGCCCTTGAAAATCTAGCCAAGTCTAGTACCAGAGGTGT
ATCTAAACCAGTTCAAACGAGTTTACCACTCAAACAGACCAATCTTTACTATGATAGCAGTCGTAATGATTTCTTTGTCA
AACCAGAGACAGTCCAAGAGGATATCAAACCACTCGTGTCAGAGTCTCCAGTTTCATCGGTAGAAAACAAACCGCAACCT
TCTGTTAAACAAGCACAACGTTCAGCAGATGAAAGTGATAGTGAACACGAAAAACTTGATTATAAAAACAAGTCGAAAAT
GAAGCGCATGCTTGAAAATCTGGACAATGAGGAAACCTCAACCTTCCCTGAGTTGGAGTTTTTTGGTCAAATGCATGGAA
CCTATCTCTTTGCTCAAGGACAAGGTGGACTTTACATCATTGACCAGCATGCTGCCCAAGAACGTGTTAAGTATGAGTAC
TATCGCGAAAAGATTGGTGAGATTGACAGTAGTTTACAACAGCTCTTGGTTCCCTATCTCTTTGAATTTTCAGGGTCAGA
TTACATTAGTTTACAAGAAAAAATGCCTCTTCTTAACCAGGTTGGTATCTATTTAGAGCCTTATGGGAATAACACCTTCA
TTCTTCGTGAACATCCTATCTGGATGAAGGAAGAAGAGATTGAATCTGCAGTCTATGAGATGTGCGACATGCTTCTTTTG
ACGAATGAAGTGTCTGTCAAAACCTACCGTGCTGAGTTAGCCATCATGATGAGTTGTAAACGTTCAATCAAGGCCAATCA
TGCTCTCGATGATTATTCTGCGCGTGACCTTCTAGTACAGCTTGCCCAGTGTAAAAACCCCTACAATTGCCCTCACGGAC
GTCCTGTACTTGTCAACTTTACAAAGTCTGATATGGAAAAAATGTTCCGTCGAATTCAAGAAAATCATACTAGTCTACGT
GACCTAGGGAAGTATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-124)

MutL C terminal dimerisation domain (MutL_C)

(446-589)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TGN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

69.725

100

0.707