Detailed information NTG0966140

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: NYE32_RS00520
• Genome accession: NZ_CP150201
• Coordinates: 84679..87129 (+)
• Length: 816 a.a.
• NCBI ID: WP_037599755.1
• Uniprot ID: A0A6N3E0F5
• Organism: Streptococcus sp. FSL R7-0248
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 79679..92129

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYE32_RS00495 (NYE32_00495)	ahpC	80591..81151 (-)	561	WP_002886340.1	alkyl hydroperoxide reductase subunit C	-
NYE32_RS00500 (NYE32_00500)	rpsB	81424..82191 (+)	768	WP_002886342.1	30S ribosomal protein S2	-
NYE32_RS00505 (NYE32_00505)	tsf	82302..83342 (+)	1041	WP_002886343.1	translation elongation factor Ts	-
NYE32_RS00510 (NYE32_00510)	-	83451..83921 (-)	471	WP_004182164.1	small multi-drug export protein	-
NYE32_RS00515 (NYE32_00515)	-	84223..84678 (+)	456	WP_002889615.1	CtsR family transcriptional regulator	-
NYE32_RS00520 (NYE32_00520)	clpC	84679..87129 (+)	2451	WP_037599755.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
NYE32_RS00525 (NYE32_00525)	pbp3	87257..88513 (-)	1257	WP_037599754.1	D-alanyl-D-alanine carboxypeptidase PBP3	-
NYE32_RS00530 (NYE32_00530)	pbp3	88658..89905 (-)	1248	WP_037599752.1	D-alanyl-D-alanine carboxypeptidase PBP3	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90253.58 Da
• Isoelectric Point: 5.9166

>NTDB_id=966140 NYE32_RS00520 WP_037599755.1 84679..87129(+) (clpC) [Streptococcus sp. FSL R7-0248]
MTTYSRKMQAIFHRAQLEAERFGSPFLETWHVLLAMVEVPGSVAYLTFTDFEDRIRAEEIETAAVLAMEKSPKDLSESDI
IDLRAQSHALEAMLQEAEGIAGVTGAVEVGSEHVLMAFLLHKDLMVCRLLEVAGFQYKDDSDKPRIIDLRRSLERYAGLS
KQDLKAIHDLRKPKKSKTSGNFANMMQPPQSSTGELADYTKDLTAVAESGALDPVIGREKEISRMIQVLSRKTKNNPVLV
GEAGVGKTALALGLAQRIASGEVPFELADMRILELDMMSVVAGTRFRGDFEERMNQIIDEIEADGKIILFIDELHTIIGS
GSGIDSTLDAANILKPALARGTLHMVGATTQAEYQKHIEKDAALSRRFAKITIEEPSVAEAIDILKGLRSSYEDYHRVTI
TDEAVETAVKAAHRYLTSKNLPDSAIDLLDEASATVQGRIKKEAKREITPLDEALLSGDMKSAVKQYKASQKAKLPKPAL
VDADQIMQTLSRLSGIPVEKMTQADSKRYLNLEAELHKRVIGQDEAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVG
KTELAKALAEVLFDDESALLRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNIL
LQVLDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVQDISHNHQAMQSRIMEELKKAYRPEFINRIDEKVV
FHSLEEEQLREIVKIMVKPLVSALAEKGIDLKFQPAALKHLAKDGYDVEMGARPLRRTIQTQVEDKLSELLLGGQVVSGQ
TLKIGCSKDKLTFTVV

Nucleotide

• Length: 2451 bp

>NTDB_id=966140 NYE32_RS00520 WP_037599755.1 84679..87129(+) (clpC) [Streptococcus sp. FSL R7-0248]
ATGACGACATATTCAAGAAAAATGCAGGCCATTTTCCATCGTGCGCAGCTTGAGGCAGAGCGTTTTGGAAGTCCTTTTCT
GGAGACTTGGCATGTGCTTCTGGCTATGGTTGAGGTTCCAGGATCTGTAGCCTACCTAACATTTACTGATTTTGAGGACC
GTATTCGTGCGGAAGAGATTGAGACAGCCGCTGTACTAGCGATGGAGAAAAGTCCAAAAGACTTGTCTGAATCAGATATT
ATCGATTTACGTGCACAGTCACATGCTTTAGAGGCTATGTTGCAAGAGGCAGAGGGAATTGCTGGTGTGACTGGTGCTGT
AGAGGTAGGGTCTGAACATGTATTGATGGCCTTTCTCCTTCATAAAGATTTGATGGTTTGTCGTCTCCTTGAAGTTGCTG
GTTTTCAATATAAGGATGACAGCGATAAGCCTCGCATTATCGATTTACGACGTTCTTTGGAGCGTTATGCAGGTCTTAGT
AAGCAAGATTTGAAGGCCATTCATGACCTTCGTAAGCCTAAAAAATCAAAGACATCAGGAAATTTTGCTAATATGATGCA
GCCTCCTCAATCTTCTACTGGGGAGTTGGCAGATTATACCAAGGACTTAACGGCAGTGGCCGAGTCAGGTGCTCTTGATC
CTGTTATTGGACGTGAGAAAGAGATTTCACGCATGATTCAGGTTTTGAGTCGTAAAACGAAGAATAACCCAGTTCTTGTA
GGTGAAGCAGGTGTTGGTAAGACGGCACTTGCGCTTGGCTTGGCACAGCGTATTGCTTCAGGCGAAGTACCTTTTGAGTT
GGCTGATATGCGTATCTTAGAGCTTGATATGATGAGTGTGGTTGCAGGAACACGTTTCCGTGGCGATTTCGAAGAGCGTA
TGAATCAAATCATTGATGAGATTGAAGCTGATGGAAAAATCATTCTCTTTATTGACGAATTGCATACGATTATTGGTTCT
GGTTCAGGTATTGATAGTACCTTAGATGCGGCAAATATTTTGAAACCTGCTCTAGCACGTGGAACTCTTCATATGGTTGG
AGCAACAACTCAAGCTGAGTACCAGAAGCATATTGAAAAAGATGCAGCTCTTTCTCGTCGTTTTGCTAAGATTACAATTG
AGGAGCCAAGTGTAGCTGAGGCGATTGATATTCTAAAAGGCCTACGTTCGTCTTATGAAGACTATCATCGTGTAACGATT
ACTGATGAAGCGGTTGAGACAGCGGTCAAGGCGGCGCATCGTTATTTGACGAGTAAAAACTTACCTGACTCTGCCATTGA
CCTTTTAGATGAAGCGAGTGCAACTGTTCAAGGTCGTATTAAAAAAGAAGCCAAACGTGAGATAACGCCCTTGGATGAAG
CGCTTCTATCTGGTGATATGAAGTCTGCTGTTAAACAATATAAGGCTAGCCAAAAAGCAAAATTACCAAAACCTGCCTTG
GTAGATGCGGATCAGATTATGCAAACCCTTAGTCGTCTATCAGGTATCCCTGTTGAGAAGATGACTCAGGCAGATAGCAA
GCGTTATTTGAATCTGGAAGCAGAGCTTCACAAACGTGTTATTGGTCAAGACGAAGCAGTTTCAGCGATTAGTCGTGCTA
TTCGTCGTAACCAGTCAGGTATTCGTACTGGAAAACGTCCGATCGGTTCCTTCATGTTCCTTGGGCCTACTGGTGTTGGT
AAGACAGAATTGGCCAAGGCATTGGCGGAAGTTCTCTTTGATGATGAGTCAGCTTTGCTTCGCTTTGACATGTCAGAATA
CATGGAAAAATTTGCGGCTAGCCGACTTAACGGTGCTCCTCCAGGTTATGTTGGCTATGATGAGGGCGGTGAGTTAACAG
AAAAAGTTCGTAATAAGCCTTACTCAGTTCTTCTCTTTGACGAGGTGGAAAAGGCTCACCCAGATATTTTCAATATTCTC
TTACAGGTTTTGGATGACGGTGTCTTGACGGATAGTCGAGGTCGTAAAGTTGACTTCTCAAATACCATTATCATTATGAC
TTCGAACTTGGGAGCGACTGCTCTTCGTGATGATAAGACCGTTGGTTTTGGAGTCCAAGACATTTCTCATAATCACCAAG
CTATGCAGTCACGTATCATGGAAGAACTTAAGAAGGCCTACCGCCCAGAGTTTATCAACCGTATTGATGAGAAGGTTGTT
TTCCATAGTCTAGAGGAAGAGCAACTTCGTGAGATTGTCAAGATTATGGTGAAACCGTTGGTATCAGCTTTGGCTGAAAA
AGGGATTGACTTGAAATTCCAACCAGCTGCCCTTAAGCATTTAGCTAAAGATGGCTATGATGTTGAGATGGGTGCTCGTC
CATTACGTCGTACGATTCAAACTCAAGTGGAGGACAAGTTATCTGAGCTCTTACTAGGTGGCCAAGTGGTTAGTGGACAA
ACCCTTAAGATCGGCTGCTCGAAAGATAAATTAACCTTTACAGTAGTGTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (724-804)

• ATPase family associated with various cellular activities (AAA) (AAA) (238-370)

• AAA domain (Cdc48 subfamily) (AAA_2) (546-717)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-46)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (109-135)

• AAA lid domain (AAA_lid_9) (377-457)

3D structure

• AlphaFold DB: A0A6N3E0F5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus thermophilus LMG 18311	95.098	100	0.951
clpC	Streptococcus thermophilus LMD-9	94.975	100	0.95
clpC	Streptococcus mutans UA159	73.039	100	0.73
clpC	Streptococcus pneumoniae TIGR4	67.279	100	0.673
clpC	Streptococcus pneumoniae Rx1	67.279	100	0.673
clpC	Streptococcus pneumoniae D39	67.279	100	0.673
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.301	100	0.512
clpC	Bacillus subtilis subsp. subtilis str. 168	47.388	100	0.478
clpE	Streptococcus mutans UA159	47.604	76.716	0.365