Detailed information NTG0962983

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: WKU35_RS09230
• Genome accession: NZ_CP150127
• Coordinates: 1892571..1893614 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus RN4220
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1887571..1898614

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WKU35_RS09200	-	1887989..1889245 (-)	1257	WP_001795438.1	aminopeptidase	-
WKU35_RS09205	-	1889248..1889448 (-)	201	WP_000180461.1	DUF1128 family protein	-
WKU35_RS09210	-	1889595..1890059 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
WKU35_RS09215	-	1890066..1890341 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
WKU35_RS09220	-	1890619..1891836 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
WKU35_RS09225	vraR	1891952..1892581 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
WKU35_RS09230	vraS	1892571..1893614 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
WKU35_RS09235	liaF	1893611..1894312 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
WKU35_RS09240	-	1894327..1894713 (-)	387	WP_001110179.1	hypothetical protein	-
WKU35_RS09245	map	1894930..1895688 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
WKU35_RS09250	-	1896216..1897202 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
WKU35_RS09255	-	1897633..1898046 (-)	414	WP_001549145.1	hypothetical protein	-
WKU35_RS09260	-	1898075..1898185 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=962983 WKU35_RS09230 WP_001017131.1 1892571..1893614(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=962983 WKU35_RS09230 WP_001017131.1 1892571..1893614(-) (vraS) [Staphylococcus aureus subsp. aureus RN4220]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1