Detailed information NTG0962065

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: ACJEIG_RS01825
• Genome accession: NZ_CP174209
• Coordinates: 389399..391975 (-)
• Length: 858 a.a.
• NCBI ID: WP_010947476.1
• Uniprot ID: Q5ZUP3
• Organism: Legionella pneumophila strain SPF666
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 384399..396975

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJEIG_RS01805 (ACJEIG_01805)	-	385055..385675 (+)	621	WP_010947480.1	hypothetical protein	-
ACJEIG_RS01810 (ACJEIG_01810)	mpl	385677..387044 (+)	1368	WP_010947479.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
ACJEIG_RS01815 (ACJEIG_01815)	-	387337..387984 (+)	648	WP_010947478.1	lpg1752 family Dot/Icm T4SS effector	-
ACJEIG_RS01820 (ACJEIG_01820)	-	387997..389307 (+)	1311	WP_010947477.1	lpg1751 family Dot/Icm T4SS effector	-
ACJEIG_RS01825 (ACJEIG_01825)	clpC	389399..391975 (-)	2577	WP_010947476.1	ATP-dependent chaperone ClpB	Regulator
ACJEIG_RS01830 (ACJEIG_01830)	-	392064..393020 (+)	957	WP_010947475.1	S49 family peptidase	-
ACJEIG_RS01835 (ACJEIG_01835)	-	393133..393918 (-)	786	WP_010947474.1	inositol monophosphatase family protein	-
ACJEIG_RS01840 (ACJEIG_01840)	trmJ	394034..394807 (+)	774	WP_010947473.1	tRNA (cytosine(32)/uridine(32)-2'-O)-methyltransferase TrmJ	-
ACJEIG_RS01845 (ACJEIG_01845)	-	394812..395945 (+)	1134	WP_016356931.1	IscS subfamily cysteine desulfurase	-
ACJEIG_RS01850 (ACJEIG_01850)	-	395942..396325 (+)	384	WP_010947471.1	iron-sulfur cluster assembly scaffold protein	-
ACJEIG_RS01855 (ACJEIG_01855)	-	396330..396698 (+)	369	WP_010947470.1	iron-sulfur cluster assembly accessory protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 95854.69 Da
• Isoelectric Point: 5.3669

>NTDB_id=962065 ACJEIG_RS01825 WP_010947476.1 389399..391975(-) (clpC) [Legionella pneumophila strain SPF666]
MRMDKLTSKFQMALADAQSLALGRDNGFIEPEHLMKALLDQQGGSCRPLLSKAGVNIPLLRTLIDQALDKLPKVSGTGGD
IHISNALNRLLNLTDKLSQQRKDNFISSELFILAAINEDSNLAKILKQAGGDNKAIEKAIDELRGGETVNDPNAEEQRQA
LEKYTLDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKNKRLLAL
DMGALIAGAKYRGEFEERLKGVLNDLAKQEGQIILFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR
QYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYEVHHGVEITDPALVAAATLSHRYISDRQLPDKAIDLIDEAASL
IRMEIDSKPESMDKLERRLIQLKIEREALKKENDEASKKRLVDLQKSIDELEQNYSDLEEIWKAEKATMQGSTQIKEALE
QAKLEMETARRAGDLSRMSELQYGRIPELEKRLSQVSSVDAMETKLVRNKVTEDEIAEVVSKWTGIPVSKMMEGEKEKLL
KMEEALHSRLIGQNEAVDAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHTDVFNILLQVMDDGRLTDGQGRTVDFRNTVIVMTSNL
GSQLIQEMSSKFNYDEIKAAVMDLVSQHFRPEFINRIDESVVFHSLTKEQIAKIAAIQINYLHHRLKQQNITIEVTSEAL
SHLAEAGFDPVYGARPLKRTIQQKLENPLAQSLLTGKFKSGDTIIVSYKDGVMEFYKQ

Nucleotide

• Length: 2577 bp

>NTDB_id=962065 ACJEIG_RS01825 WP_010947476.1 389399..391975(-) (clpC) [Legionella pneumophila strain SPF666]
ATGCGAATGGACAAACTAACATCAAAGTTTCAAATGGCACTTGCAGATGCCCAATCCCTGGCTTTAGGTAGAGACAATGG
ATTTATAGAACCAGAACATTTAATGAAGGCCTTGCTTGATCAGCAAGGTGGAAGTTGCAGACCTCTTCTCAGTAAAGCGG
GTGTTAATATACCACTATTAAGAACTTTAATTGACCAAGCTCTGGATAAACTACCTAAAGTATCAGGCACCGGAGGAGAT
ATTCACATATCTAATGCATTGAATAGACTACTTAACCTGACTGACAAATTATCGCAACAAAGAAAAGATAACTTTATTTC
AAGCGAGCTTTTTATATTAGCAGCGATAAATGAGGATAGTAACCTTGCAAAAATACTTAAACAAGCCGGGGGTGACAACA
AAGCAATTGAAAAAGCAATTGATGAGTTAAGAGGTGGAGAAACGGTTAATGATCCAAATGCAGAGGAACAGCGACAAGCC
CTTGAAAAATATACACTGGATCTGACTGAACGTGCCGAGCAAGGAAAATTGGATCCAGTTATTGGACGAGATGATGAAAT
CAGACGCACCATCCAGGTATTGCAAAGAAGAACTAAAAATAACCCTGTATTAATAGGTGAACCTGGTGTTGGTAAAACAG
CCATAGTAGAAGGTTTGGCACAACGAATTATTAATGGTGAAGTACCTGAAGGATTAAAGAATAAACGCTTACTGGCGCTG
GACATGGGTGCCTTGATCGCAGGTGCAAAATATCGTGGAGAGTTTGAAGAACGCTTAAAAGGGGTGCTTAATGATTTGGC
AAAACAAGAGGGTCAAATCATATTATTTATTGATGAATTACACACTATGGTTGGCGCTGGCAAGGCTGAAGGAGCTATGG
ATGCCGGGAATATGCTCAAGCCAGCATTAGCTAGAGGTGAATTGCATTGCATTGGGGCTACGACATTAGACGAATACCGA
CAATACATTGAAAAGGATGCTGCCCTTGAACGACGTTTTCAAAAAGTACTGGTCGATGAACCCAGTGTGGAAGACACTAT
CGCTATATTAAGGGGACTTAAGGAACGTTATGAAGTTCACCATGGAGTTGAAATTACAGATCCCGCTTTGGTTGCTGCAG
CAACGCTATCCCATCGTTACATCAGCGACCGTCAACTACCTGATAAAGCCATTGATTTAATTGACGAGGCCGCCAGCTTA
ATCCGGATGGAAATTGATTCAAAACCAGAAAGTATGGATAAACTGGAACGACGCTTGATTCAGCTAAAAATCGAGCGTGA
AGCATTGAAAAAGGAAAATGACGAAGCATCTAAAAAAAGACTTGTTGATTTACAAAAAAGTATCGATGAATTAGAGCAAA
ATTATTCAGACTTAGAAGAAATTTGGAAAGCTGAAAAAGCGACCATGCAAGGGTCCACTCAAATCAAAGAGGCACTTGAG
CAAGCCAAACTGGAAATGGAAACTGCAAGGAGAGCAGGAGATTTAAGTCGTATGTCCGAATTACAATATGGACGTATACC
CGAGTTGGAAAAAAGATTAAGCCAAGTCTCTTCCGTTGATGCTATGGAAACAAAGTTGGTACGCAATAAAGTCACCGAAG
ATGAGATCGCAGAAGTTGTTTCAAAATGGACAGGAATCCCAGTATCTAAAATGATGGAAGGAGAAAAGGAAAAACTGCTG
AAAATGGAAGAAGCTTTGCACAGTAGACTCATTGGCCAGAATGAAGCGGTGGATGCTGTTTCTAATGCCATAAGACGGTC
ACGCGCAGGCCTGTCTGATCCTAATCGTCCAATTGGTTCATTTCTTTTTCTGGGGCCAACTGGTGTGGGAAAAACTGAAC
TATGTAAAGCACTTGCTTCTTTTCTTTTTGATACGGAAGAGGCGATGGTGCGCATTGATATGTCTGAATTTATGGAAAAA
CACTCTGTTGCGCGCTTAATCGGAGCGCCTCCTGGCTATGTAGGATATGAGGAGGGTGGCTATTTAACTGAAGCAGTCAG
ACGCAGACCCTATTCTGTTATCTTACTTGATGAAGTAGAAAAAGCTCATACAGATGTATTTAATATTCTGCTTCAAGTGA
TGGATGATGGCCGTCTAACAGATGGTCAGGGACGTACTGTTGACTTTAGGAATACCGTTATTGTTATGACCTCTAATCTG
GGATCTCAACTCATTCAGGAAATGAGCAGCAAATTTAATTACGATGAGATTAAGGCTGCGGTAATGGATTTAGTCAGCCA
ACATTTCAGGCCTGAATTTATCAACAGAATTGATGAATCGGTGGTATTCCATTCCCTGACAAAAGAACAAATTGCAAAAA
TTGCAGCAATCCAGATTAACTATTTACATCATCGGCTGAAACAACAAAATATCACTATTGAAGTCACAAGTGAGGCTTTA
TCTCATTTGGCTGAAGCAGGTTTTGACCCGGTCTATGGTGCCCGCCCCCTAAAACGTACTATTCAGCAAAAATTAGAGAA
TCCACTAGCTCAATCATTATTGACTGGAAAATTTAAATCCGGGGATACCATTATTGTATCTTATAAAGATGGAGTAATGG
AATTTTACAAGCAATGA

Domains

Predicted by InterProScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-846)

• AAA lid domain (AAA_lid_9) (342-444)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-759)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-335)

3D structure

• AlphaFold DB: Q5ZUP3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.181	100	0.478
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.061	100	0.415
clpC	Lactococcus lactis subsp. cremoris KW2	46.31	80.536	0.373
clpE	Streptococcus mutans UA159	45.95	79.138	0.364
clpE	Streptococcus pneumoniae TIGR4	45.283	80.303	0.364
clpE	Streptococcus pneumoniae Rx1	45.283	80.303	0.364
clpE	Streptococcus pneumoniae D39	45.283	80.303	0.364
clpE	Streptococcus pneumoniae R6	45.283	80.303	0.364