Detailed information NTG0961560

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: UXR74_RS09380
• Genome accession: NZ_CP149805
• Coordinates: 1917126..1918169 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN122
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1912126..1923169

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UXR74_RS09350 (UXR74_09350)	-	1912544..1913800 (-)	1257	WP_001795438.1	aminopeptidase	-
UXR74_RS09355 (UXR74_09355)	-	1913803..1914003 (-)	201	WP_000180461.1	DUF1128 family protein	-
UXR74_RS09360 (UXR74_09360)	-	1914150..1914614 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
UXR74_RS09365 (UXR74_09365)	-	1914621..1914896 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
UXR74_RS09370 (UXR74_09370)	-	1915174..1916391 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
UXR74_RS09375 (UXR74_09375)	vraR	1916507..1917136 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
UXR74_RS09380 (UXR74_09380)	vraS	1917126..1918169 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
UXR74_RS09385 (UXR74_09385)	liaF	1918166..1918867 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
UXR74_RS09390 (UXR74_09390)	-	1918882..1919268 (-)	387	WP_001110179.1	hypothetical protein	-
UXR74_RS09395 (UXR74_09395)	map	1919485..1920243 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
UXR74_RS09400 (UXR74_09400)	-	1920830..1921816 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
UXR74_RS09405 (UXR74_09405)	-	1922306..1922719 (-)	414	WP_001549145.1	hypothetical protein	-
UXR74_RS09410 (UXR74_09410)	-	1922748..1922858 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=961560 UXR74_RS09380 WP_001017131.1 1917126..1918169(-) (vraS) [Staphylococcus aureus strain BSN122]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=961560 UXR74_RS09380 WP_001017131.1 1917126..1918169(-) (vraS) [Staphylococcus aureus strain BSN122]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1