Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | WJ060_RS00485 | Genome accession | NZ_CP149492 |
| Coordinates | 97577..98923 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain BPH2947 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40374..98923 | 97577..98923 | within | 0 |
Gene organization within MGE regions
Location: 40374..98923
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WJ060_RS00165 (WJ060_00165) | ccrC | 40374..42059 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| WJ060_RS00170 (WJ060_00170) | tnpA | 42107..42592 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| WJ060_RS00175 (WJ060_00175) | - | 42884..43222 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WJ060_RS00180 (WJ060_00180) | - | 43316..43627 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| WJ060_RS00185 (WJ060_00185) | - | 43643..44149 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| WJ060_RS00190 (WJ060_00190) | - | 44170..44487 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| WJ060_RS00195 (WJ060_00195) | - | 44606..45691 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| WJ060_RS00200 (WJ060_00200) | - | 45688..47580 (+) | 1893 | WP_014532403.1 | site-specific integrase | - |
| WJ060_RS00205 (WJ060_00205) | - | 47587..47964 (+) | 378 | WP_001041907.1 | DUF6262 family protein | - |
| WJ060_RS00210 (WJ060_00210) | - | 48115..48897 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| WJ060_RS00215 (WJ060_00215) | erm(A) | 49023..49754 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| WJ060_RS00220 | - | 49812..49871 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| WJ060_RS00225 (WJ060_00220) | - | 50263..50925 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| WJ060_RS00230 (WJ060_00225) | - | 51157..51303 (+) | 147 | Protein_43 | JAB domain-containing protein | - |
| WJ060_RS00235 (WJ060_00230) | - | 51473..52345 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| WJ060_RS00240 (WJ060_00235) | - | 52402..52692 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| WJ060_RS00245 (WJ060_00240) | - | 52708..53196 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| WJ060_RS00250 (WJ060_00245) | - | 53331..53858 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| WJ060_RS00255 (WJ060_00250) | - | 53920..54336 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| WJ060_RS00260 (WJ060_00255) | - | 54625..54789 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| WJ060_RS00265 (WJ060_00260) | - | 54803..55024 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| WJ060_RS00270 (WJ060_00265) | - | 55174..55740 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| WJ060_RS00275 (WJ060_00270) | - | 55820..58033 (-) | 2214 | Protein_52 | type I restriction endonuclease subunit R | - |
| WJ060_RS00280 (WJ060_00275) | - | 58095..58769 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| WJ060_RS00285 (WJ060_00280) | - | 59052..60398 (+) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| WJ060_RS00290 (WJ060_00285) | merR | 60698..61105 (+) | 408 | WP_000525462.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| WJ060_RS00295 (WJ060_00290) | - | 61122..61607 (+) | 486 | WP_000746202.1 | TlpA disulfide reductase family protein | - |
| WJ060_RS00300 (WJ060_00295) | - | 61604..62284 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| WJ060_RS00305 (WJ060_00300) | - | 62419..62757 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| WJ060_RS00310 (WJ060_00305) | merA | 62815..64458 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| WJ060_RS00315 (WJ060_00310) | merB | 64540..65190 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| WJ060_RS00320 (WJ060_00315) | - | 65385..65900 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| WJ060_RS00325 (WJ060_00320) | - | 66019..66693 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| WJ060_RS00330 (WJ060_00325) | - | 67028..68200 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| WJ060_RS00335 (WJ060_00330) | - | 68458..68790 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| WJ060_RS00340 (WJ060_00335) | - | 68819..69061 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| WJ060_RS00345 (WJ060_00340) | - | 69193..69867 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| WJ060_RS00350 (WJ060_00345) | tet(K) | 70064..71443 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| WJ060_RS00355 (WJ060_00350) | mobV | 71632..72873 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| WJ060_RS00360 (WJ060_00355) | - | 73400..74354 (+) | 955 | Protein_69 | replication initiation factor domain-containing protein | - |
| WJ060_RS00365 (WJ060_00360) | - | 74443..75117 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| WJ060_RS00370 (WJ060_00365) | - | 75153..75542 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| WJ060_RS00375 (WJ060_00370) | - | 76499..77242 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| WJ060_RS00380 (WJ060_00375) | - | 77339..77767 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| WJ060_RS00385 (WJ060_00380) | mecA | 77813..79822 (-) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| WJ060_RS00390 (WJ060_00385) | mecR1 | 79919..81676 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| WJ060_RS00395 (WJ060_00390) | mecI | 81676..82047 (+) | 372 | Protein_76 | mecA-type methicillin resistance repressor MecI | - |
| WJ060_RS00400 (WJ060_00395) | psm-mec | 82132..82200 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| WJ060_RS00405 (WJ060_00400) | - | 82520..83668 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| WJ060_RS00410 (WJ060_00405) | cstB | 83782..85116 (-) | 1335 | Protein_79 | persulfide dioxygenase-sulfurtransferase CstB | - |
| WJ060_RS00415 (WJ060_00410) | - | 85148..86212 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| WJ060_RS00420 (WJ060_00415) | cstR | 86348..86608 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| WJ060_RS00425 (WJ060_00420) | - | 86608..87246 (+) | 639 | Protein_82 | sulfite exporter TauE/SafE family protein | - |
| WJ060_RS00430 (WJ060_00425) | - | 87520..88137 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| WJ060_RS00435 (WJ060_00430) | - | 88218..90632 (-) | 2415 | WP_000378486.1 | cadmium-translocating P-type ATPase CadA | - |
| WJ060_RS00440 (WJ060_00435) | - | 90625..90990 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| WJ060_RS00445 (WJ060_00440) | - | 91176..91553 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| WJ060_RS00450 (WJ060_00445) | - | 91560..93452 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| WJ060_RS00455 (WJ060_00450) | - | 93647..93970 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| WJ060_RS00460 (WJ060_00455) | - | 93963..94169 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| WJ060_RS00465 (WJ060_00460) | - | 94171..94692 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| WJ060_RS00470 (WJ060_00465) | - | 94711..95022 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| WJ060_RS00475 (WJ060_00470) | - | 95107..95457 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| WJ060_RS00480 (WJ060_00475) | ccrB | 95928..97556 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| WJ060_RS00485 (WJ060_00480) | ccrA | 97577..98923 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=959509 WJ060_RS00485 WP_000816499.1 97577..98923(-) (ccrA) [Staphylococcus aureus strain BPH2947]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=959509 WJ060_RS00485 WP_000816499.1 97577..98923(-) (ccrA) [Staphylococcus aureus strain BPH2947]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |