Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   WJ062_RS05580 Genome accession   NZ_CP149486
Coordinates   1135410..1137215 (-) Length   601 a.a.
NCBI ID   WP_136119896.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain EMM113     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1101117..1135078 1135410..1137215 flank 332


Gene organization within MGE regions


Location: 1101117..1137215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WJ062_RS05440 (WJ062_05410) - 1101342..1102601 (-) 1260 WP_002989295.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  WJ062_RS05445 (WJ062_05415) metK 1102775..1103971 (-) 1197 WP_002989292.1 methionine adenosyltransferase -
  WJ062_RS05450 (WJ062_05420) - 1104507..1106885 (-) 2379 WP_136119908.1 leucine-rich repeat domain-containing protein -
  WJ062_RS05455 (WJ062_05425) birA 1107089..1108030 (+) 942 WP_002989286.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
  WJ062_RS05460 (WJ062_05430) - 1108005..1108208 (-) 204 WP_002992607.1 DUF3272 family protein -
  WJ062_RS05465 (WJ062_05435) - 1108350..1109483 (-) 1134 WP_406848694.1 ISAs1-like element IS1548 family transposase -
  WJ062_RS05470 (WJ062_05440) dnaX 1109753..1111438 (-) 1686 WP_002989266.1 DNA polymerase III subunit gamma/tau -
  WJ062_RS05475 (WJ062_05445) - 1111438..1111935 (-) 498 WP_136021578.1 GAF domain-containing protein -
  WJ062_RS05480 (WJ062_05450) - 1112080..1112889 (+) 810 WP_002989260.1 PrsW family intramembrane metalloprotease -
  WJ062_RS05485 (WJ062_05455) - 1112942..1113205 (-) 264 WP_002989257.1 DUF1294 domain-containing protein -
  WJ062_RS05490 (WJ062_05460) udk 1113285..1113911 (-) 627 WP_002984060.1 uridine kinase -
  WJ062_RS05495 (WJ062_05465) - 1114009..1115094 (+) 1086 WP_002989254.1 DEAD/DEAH box helicase -
  WJ062_RS05500 (WJ062_05470) - 1115205..1116479 (-) 1275 WP_002989251.1 polysaccharide deacetylase family protein -
  WJ062_RS05505 (WJ062_05475) - 1116575..1118002 (-) 1428 WP_002989248.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  WJ062_RS05510 (WJ062_05480) ptsP 1118187..1119920 (-) 1734 WP_002989245.1 phosphoenolpyruvate--protein phosphotransferase -
  WJ062_RS05515 (WJ062_05485) - 1119925..1120188 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  WJ062_RS05520 (WJ062_05490) - 1120581..1120799 (+) 219 WP_002989242.1 redoxin NrdH -
  WJ062_RS05525 (WJ062_05495) nrdE 1120819..1122978 (+) 2160 WP_136119945.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  WJ062_RS05530 (WJ062_05500) nrdF 1123300..1124259 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  WJ062_RS05535 (WJ062_05505) - 1124321..1125547 (+) 1227 WP_021340858.1 chloride channel protein -
  WJ062_RS05540 (WJ062_05510) - 1125643..1126799 (+) 1157 Protein_1045 IS3 family transposase -
  WJ062_RS05545 (WJ062_05515) - 1126893..1127588 (-) 696 WP_406848695.1 lysostaphin resistance A-like protein -
  WJ062_RS05550 (WJ062_05520) - 1127607..1128368 (-) 762 WP_002995753.1 DUF3169 family protein -
  WJ062_RS05555 (WJ062_05525) - 1128365..1128580 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  WJ062_RS05560 (WJ062_05530) alaS 1128941..1131559 (-) 2619 WP_002989217.1 alanine--tRNA ligase -
  WJ062_RS05565 (WJ062_05535) prsA 1131946..1133001 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  WJ062_RS05570 (WJ062_05540) - 1133064..1133771 (-) 708 WP_002989211.1 O-methyltransferase -
  WJ062_RS05575 (WJ062_05545) - 1133837..1135033 (-) 1197 WP_002989208.1 OFA family MFS transporter -
  WJ062_RS05580 (WJ062_05550) pepF 1135410..1137215 (-) 1806 WP_136119896.1 oligoendopeptidase F Regulator

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69385.24 Da        Isoelectric Point: 4.7093

>NTDB_id=959439 WJ062_RS05580 WP_136119896.1 1135410..1137215(-) (pepF) [Streptococcus pyogenes strain EMM113]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKVSGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMTKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=959439 WJ062_RS05580 WP_136119896.1 1135410..1137215(-) (pepF) [Streptococcus pyogenes strain EMM113]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGTTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTAGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAGATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGACAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.048

100

0.71