Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   QMM33_RS06005 Genome accession   NZ_AP025940
Coordinates   1181823..1184063 (-) Length   746 a.a.
NCBI ID   WP_050207195.1    Uniprot ID   A0A4J2FH25
Organism   Streptococcus pneumoniae strain PZ900700204     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1176823..1189063
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QMM33_RS05970 (PC0204_11700) - 1177732..1178112 (-) 381 WP_000157154.1 VOC family protein -
  QMM33_RS05975 (PC0204_11710) rplT 1178170..1178529 (-) 360 WP_050207197.1 50S ribosomal protein L20 -
  QMM33_RS05980 (PC0204_11720) rpmI 1178581..1178781 (-) 201 WP_001125943.1 50S ribosomal protein L35 -
  QMM33_RS05985 (PC0204_11730) infC 1178814..1179344 (-) 531 WP_000848180.1 translation initiation factor IF-3 -
  QMM33_RS05990 (PC0204_11740) - 1179651..1180832 (-) 1182 WP_000655951.1 membrane protein -
  QMM33_RS05995 (PC0204_11750) - 1180836..1181423 (-) 588 WP_000939886.1 ABC transporter ATP-binding protein -
  QMM33_RS06000 (PC0204_11760) - 1181456..1181644 (-) 189 WP_050207196.1 hypothetical protein -
  QMM33_RS06005 (PC0204_11770) comEC/celB 1181823..1184063 (-) 2241 WP_050207195.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  QMM33_RS06010 (PC0204_11780) comEA/celA/cilE 1184047..1184697 (-) 651 WP_001864147.1 helix-hairpin-helix domain-containing protein Machinery gene
  QMM33_RS06015 (PC0204_11790) - 1184765..1185334 (-) 570 WP_001864145.1 GNAT family N-acetyltransferase -
  QMM33_RS06020 ald 1185511..1186622 (+) 1112 Protein_1198 alanine dehydrogenase -
  QMM33_RS06025 (PC0204_11830) - 1186923..1187249 (-) 327 Protein_1199 TfoX/Sxy family protein -
  QMM33_RS06030 (PC0204_11840) - 1187252..1187752 (-) 501 WP_000566983.1 GNAT family N-acetyltransferase -
  QMM33_RS06035 (PC0204_11850) - 1187945..1188913 (-) 969 WP_000658183.1 PhoH family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84561.01 Da        Isoelectric Point: 9.5181

>NTDB_id=95510 QMM33_RS06005 WP_050207195.1 1181823..1184063(-) (comEC/celB) [Streptococcus pneumoniae strain PZ900700204]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
ENVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQTTQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKTSQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=95510 QMM33_RS06005 WP_050207195.1 1181823..1184063(-) (comEC/celB) [Streptococcus pneumoniae strain PZ900700204]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGCTTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGAATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGACGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAACTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Domain of unknown function (DUF4131) (DUF4131)

(30-176)

Competence protein (Competence)

(216-458)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-697)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J2FH25

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

97.989

100

0.98
  comEC/celB Streptococcus pneumoniae D39

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae R6

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae Rx1

97.721

100

0.977
  comEC/celB Streptococcus mitis NCTC 12261

91.812

99.866

0.917
  comEC/celB Streptococcus mitis SK321

91.555

100

0.916
  comEC Lactococcus lactis subsp. cremoris KW2

44.13

99.33

0.438

Multiple sequence alignment