Detailed information
Bioinformatically predicted
Overview
| Name | covS | Type | Regulator |
| Locus tag | V4331_RS02345 | Genome accession | NZ_CP146743 |
| Coordinates | 471364..472854 (+) | Length | 496 a.a. |
| NCBI ID | WP_341784298.1 | Uniprot ID | - |
| Organism | Lactococcus formosensis subsp. formosensis strain L5 | ||
| Function | repress the expression of comX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 406983..487379 | 471364..472854 | within | 0 |
Gene organization within MGE regions
Location: 406983..487379
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V4331_RS02055 (V4331_02060) | - | 407638..408219 (+) | 582 | WP_252175593.1 | uracil-DNA glycosylase family protein | - |
| V4331_RS02060 (V4331_02065) | - | 408316..408762 (-) | 447 | WP_096368645.1 | GNAT family N-acetyltransferase | - |
| V4331_RS02065 (V4331_02070) | - | 408872..409993 (+) | 1122 | WP_096368644.1 | AI-2E family transporter | - |
| V4331_RS02070 (V4331_02075) | - | 410039..411367 (+) | 1329 | WP_017368823.1 | hemolysin family protein | - |
| V4331_RS02075 (V4331_02080) | - | 411481..412941 (+) | 1461 | WP_096368643.1 | DHA2 family efflux MFS transporter permease subunit | - |
| V4331_RS02080 (V4331_02085) | pflA | 413008..413802 (+) | 795 | WP_017368825.1 | pyruvate formate-lyase-activating protein | - |
| V4331_RS02085 (V4331_02090) | - | 413948..414892 (+) | 945 | WP_014024319.1 | manganese-dependent inorganic pyrophosphatase | - |
| V4331_RS02090 (V4331_02095) | - | 414892..415656 (+) | 765 | WP_341784282.1 | DUF1803 domain-containing protein | - |
| V4331_RS02095 (V4331_02100) | pepT | 415659..416900 (+) | 1242 | WP_341784283.1 | peptidase T | - |
| V4331_RS02100 (V4331_02105) | yjeM | 417238..418839 (+) | 1602 | WP_341784284.1 | glutamate/gamma-aminobutyrate family transporter YjeM | - |
| V4331_RS02105 (V4331_02110) | - | 418902..420353 (-) | 1452 | WP_096368639.1 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase | - |
| V4331_RS02110 (V4331_02115) | - | 420548..421435 (-) | 888 | WP_096368638.1 | helix-turn-helix domain-containing protein | - |
| V4331_RS02115 (V4331_02120) | - | 421716..422216 (+) | 501 | WP_341784285.1 | hypothetical protein | - |
| V4331_RS02120 (V4331_02125) | - | 422411..422779 (+) | 369 | WP_231951183.1 | hypothetical protein | - |
| V4331_RS02125 (V4331_02130) | - | 422891..424609 (+) | 1719 | WP_341784286.1 | polysaccharide biosynthesis protein | - |
| V4331_RS02130 (V4331_02135) | - | 424708..426591 (+) | 1884 | WP_096368635.1 | M13-type metalloendopeptidase | - |
| V4331_RS02135 (V4331_02140) | - | 426585..426911 (+) | 327 | WP_096368634.1 | MGMT family protein | - |
| V4331_RS02140 (V4331_02145) | rpoB | 427180..430770 (+) | 3591 | WP_017368838.1 | DNA-directed RNA polymerase subunit beta | - |
| V4331_RS02145 (V4331_02150) | rpoC | 431090..434737 (+) | 3648 | WP_341784492.1 | DNA-directed RNA polymerase subunit beta' | - |
| V4331_RS02150 (V4331_02155) | - | 434828..435736 (-) | 909 | WP_096368633.1 | diacylglycerol kinase family protein | - |
| V4331_RS02155 (V4331_02160) | mecA | 435984..436667 (+) | 684 | WP_096368632.1 | adaptor protein MecA | Regulator |
| V4331_RS02160 (V4331_02165) | - | 436671..437927 (+) | 1257 | WP_096368631.1 | glycosyltransferase family 4 protein | - |
| V4331_RS02165 (V4331_02170) | sufC | 438005..438775 (+) | 771 | WP_017368843.1 | Fe-S cluster assembly ATPase SufC | - |
| V4331_RS02170 (V4331_02175) | sufD | 438845..440101 (+) | 1257 | WP_341784287.1 | Fe-S cluster assembly protein SufD | - |
| V4331_RS02175 (V4331_02180) | - | 440101..441312 (+) | 1212 | WP_341784288.1 | cysteine desulfurase | - |
| V4331_RS02180 (V4331_02185) | sufU | 441337..441792 (+) | 456 | WP_096368628.1 | Fe-S cluster assembly sulfur transfer protein SufU | - |
| V4331_RS02185 (V4331_02190) | sufB | 441817..443214 (+) | 1398 | WP_165711421.1 | Fe-S cluster assembly protein SufB | - |
| V4331_RS02190 (V4331_02195) | - | 443513..445069 (+) | 1557 | WP_096368626.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| V4331_RS02195 (V4331_02200) | - | 445235..446410 (+) | 1176 | WP_341784289.1 | SLC13 family permease | - |
| V4331_RS02200 (V4331_02205) | - | 446468..447109 (+) | 642 | WP_341784290.1 | helix-hairpin-helix domain-containing protein | - |
| V4331_RS02205 (V4331_02210) | - | 447129..447995 (+) | 867 | WP_341784291.1 | ComEC/Rec2 family competence protein | - |
| V4331_RS02215 (V4331_02220) | - | 448091..449032 (-) | 942 | Protein_425 | transposase | - |
| V4331_RS02220 (V4331_02225) | - | 449316..450092 (+) | 777 | WP_341784292.1 | alpha/beta hydrolase family protein | - |
| V4331_RS02225 (V4331_02230) | - | 450288..450503 (+) | 216 | WP_003135074.1 | F0F1 ATP synthase subunit C | - |
| V4331_RS02230 (V4331_02235) | atpB | 450558..451271 (+) | 714 | WP_017368853.1 | F0F1 ATP synthase subunit A | - |
| V4331_RS02235 (V4331_02240) | atpF | 451285..451791 (+) | 507 | WP_017368854.1 | F0F1 ATP synthase subunit B | - |
| V4331_RS02240 (V4331_02245) | - | 451806..452333 (+) | 528 | WP_017368855.1 | F0F1 ATP synthase subunit delta | - |
| V4331_RS02245 (V4331_02250) | atpA | 452399..453907 (+) | 1509 | WP_004259170.1 | F0F1 ATP synthase subunit alpha | - |
| V4331_RS02250 (V4331_02255) | - | 453919..454800 (+) | 882 | WP_017368856.1 | F0F1 ATP synthase subunit gamma | - |
| V4331_RS02255 (V4331_02260) | atpD | 454860..456269 (+) | 1410 | WP_004259151.1 | F0F1 ATP synthase subunit beta | - |
| V4331_RS02260 (V4331_02265) | - | 456287..456712 (+) | 426 | WP_017368857.1 | F0F1 ATP synthase subunit epsilon | - |
| V4331_RS02265 (V4331_02270) | - | 456895..457566 (+) | 672 | WP_341784494.1 | hypothetical protein | - |
| V4331_RS02270 (V4331_02275) | - | 457597..458385 (+) | 789 | WP_252175610.1 | hypothetical protein | - |
| V4331_RS02275 (V4331_02280) | - | 458473..459390 (+) | 918 | WP_341784293.1 | lactate/malate family dehydrogenase | - |
| V4331_RS02280 (V4331_02285) | - | 459504..460208 (+) | 705 | WP_096368620.1 | histidine phosphatase family protein | - |
| V4331_RS02285 (V4331_02290) | - | 460192..460977 (+) | 786 | WP_341784294.1 | M15 family metallopeptidase | - |
| V4331_RS02290 (V4331_02295) | - | 461012..461416 (+) | 405 | WP_096368618.1 | hypothetical protein | - |
| V4331_RS02295 (V4331_02300) | hrcA | 461555..462592 (+) | 1038 | WP_004259126.1 | heat-inducible transcriptional repressor HrcA | - |
| V4331_RS02300 (V4331_02305) | grpE | 462596..463168 (+) | 573 | WP_269457347.1 | nucleotide exchange factor GrpE | - |
| V4331_RS02305 (V4331_02310) | dnaK | 463246..465072 (+) | 1827 | WP_017368866.1 | molecular chaperone DnaK | - |
| V4331_RS02310 (V4331_02315) | - | 465223..465621 (+) | 399 | WP_017368867.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| V4331_RS02315 (V4331_02320) | - | 465798..466499 (+) | 702 | WP_096368616.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| V4331_RS02320 (V4331_02325) | pfkB | 466496..467413 (+) | 918 | WP_341784295.1 | 1-phosphofructokinase | - |
| V4331_RS02325 (V4331_02330) | - | 467447..469351 (+) | 1905 | WP_341784296.1 | fructose-specific PTS transporter subunit EIIC | - |
| V4331_RS02330 (V4331_02335) | - | 469463..469705 (+) | 243 | WP_003135050.1 | type B 50S ribosomal protein L31 | - |
| V4331_RS02335 (V4331_02340) | - | 469923..470480 (+) | 558 | WP_341784297.1 | YceD family protein | - |
| V4331_RS02340 (V4331_02345) | covR | 470581..471276 (+) | 696 | WP_017368870.1 | response regulator transcription factor | Regulator |
| V4331_RS02345 (V4331_02350) | covS | 471364..472854 (+) | 1491 | WP_341784298.1 | HAMP domain-containing histidine kinase | Regulator |
| V4331_RS02350 (V4331_02355) | - | 473250..474821 (+) | 1572 | WP_341784299.1 | ABC transporter permease subunit | - |
| V4331_RS02355 (V4331_02360) | - | 474822..475559 (+) | 738 | WP_096368611.1 | amino acid ABC transporter ATP-binding protein | - |
| V4331_RS02360 (V4331_02365) | murD | 475699..477060 (+) | 1362 | WP_341784300.1 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase | - |
| V4331_RS02365 (V4331_02370) | murG | 477062..478156 (+) | 1095 | WP_341784301.1 | undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase | - |
| V4331_RS02370 (V4331_02375) | - | 478156..479196 (+) | 1041 | WP_096368608.1 | cell division protein FtsQ/DivIB | - |
| V4331_RS02375 (V4331_02380) | - | 479285..480022 (-) | 738 | WP_004259074.1 | amino acid ABC transporter ATP-binding protein | - |
| V4331_RS02380 (V4331_02385) | - | 480036..482180 (-) | 2145 | WP_341784302.1 | amino acid ABC transporter substrate-binding protein/permease | - |
| V4331_RS02385 (V4331_02390) | - | 482419..483075 (+) | 657 | WP_014024359.1 | VTT domain-containing protein | - |
| V4331_RS02390 (V4331_02395) | - | 483144..484010 (+) | 867 | WP_341784303.1 | shikimate dehydrogenase | - |
| V4331_RS02395 (V4331_02400) | aroB | 483994..485055 (+) | 1062 | WP_341784304.1 | 3-dehydroquinate synthase | - |
| V4331_RS02400 (V4331_02405) | - | 485106..485537 (+) | 432 | WP_341784305.1 | DUF1697 domain-containing protein | - |
| V4331_RS02405 (V4331_02410) | - | 485537..486463 (+) | 927 | WP_341784306.1 | DMT family transporter | - |
| V4331_RS02410 (V4331_02415) | - | 486470..487060 (+) | 591 | WP_341784307.1 | DUF1054 domain-containing protein | - |
Sequence
Protein
Download Length: 496 a.a. Molecular weight: 56889.89 Da Isoelectric Point: 5.2104
>NTDB_id=944009 V4331_RS02345 WP_341784298.1 471364..472854(+) (covS) [Lactococcus formosensis subsp. formosensis strain L5]
MVKFFDSKKKKTESLPERKRSIMLRWAFANTIFCFITFTIFTVLVYQLTITTFINSEKEDMMRALNNVEQSLSQSVNKLS
EENLANYLAYAKGYTASSQGRENELETLGSMIGSRKSFYVFDVGENLIYSTNSYGFRLRKDVGDSSQAVRTFGEYSGYLV
ERPVHSKKTGELIGYVQAFYDMSYYYSVRTKLLVALIILEIIALFIAQFVGYFMASRYIKPLERLHDAITTRANNLKADF
KPVVIQTGDEIEELATVYNDMMIKLNDYVDQQKRFVSDVSHELRTPLSVLDGHLNLLNRWGKNDPEVLEESLQASIEEVS
TMRTMLEEMLALARLESIDFQDEDLICDPTEVSNFLKKNFLLIHPDLKLTVENDLPSGRLAHIYPNHYEQGLKILIDNAI
KYSPEDRQEVKIHLEEDDEYIITTVGDRGYGISQEDLKHVFERFFRADKARNRDIGGTGLGLSIIQRIVENYEGDVSVTS
VVGEGSKFTLKIPKIK
MVKFFDSKKKKTESLPERKRSIMLRWAFANTIFCFITFTIFTVLVYQLTITTFINSEKEDMMRALNNVEQSLSQSVNKLS
EENLANYLAYAKGYTASSQGRENELETLGSMIGSRKSFYVFDVGENLIYSTNSYGFRLRKDVGDSSQAVRTFGEYSGYLV
ERPVHSKKTGELIGYVQAFYDMSYYYSVRTKLLVALIILEIIALFIAQFVGYFMASRYIKPLERLHDAITTRANNLKADF
KPVVIQTGDEIEELATVYNDMMIKLNDYVDQQKRFVSDVSHELRTPLSVLDGHLNLLNRWGKNDPEVLEESLQASIEEVS
TMRTMLEEMLALARLESIDFQDEDLICDPTEVSNFLKKNFLLIHPDLKLTVENDLPSGRLAHIYPNHYEQGLKILIDNAI
KYSPEDRQEVKIHLEEDDEYIITTVGDRGYGISQEDLKHVFERFFRADKARNRDIGGTGLGLSIIQRIVENYEGDVSVTS
VVGEGSKFTLKIPKIK
Nucleotide
Download Length: 1491 bp
>NTDB_id=944009 V4331_RS02345 WP_341784298.1 471364..472854(+) (covS) [Lactococcus formosensis subsp. formosensis strain L5]
ATGGTAAAATTTTTTGATTCTAAGAAGAAAAAAACAGAAAGTCTTCCAGAGCGTAAGCGGAGCATCATGCTACGTTGGGC
ATTTGCAAATACGATTTTTTGTTTTATTACTTTCACTATTTTTACAGTATTGGTTTATCAACTAACGATAACTACTTTCA
TCAATTCTGAAAAAGAGGATATGATGAGGGCTTTAAATAATGTTGAACAAAGTCTGTCCCAATCGGTAAACAAACTGTCA
GAAGAAAATCTTGCGAATTATTTGGCTTATGCCAAAGGCTATACAGCCTCCAGTCAGGGAAGAGAAAATGAACTTGAAAC
ACTAGGAAGTATGATTGGTTCAAGAAAGTCCTTTTATGTCTTCGATGTAGGTGAGAACCTGATTTACTCGACCAATTCGT
ATGGTTTTCGTCTAAGGAAAGATGTGGGTGATTCATCGCAAGCTGTACGTACATTTGGCGAATATTCTGGTTATTTGGTT
GAGCGACCCGTGCATTCTAAAAAAACGGGAGAACTGATCGGCTATGTACAGGCTTTTTATGATATGAGCTATTATTATAG
TGTGCGTACAAAGCTACTTGTTGCCTTGATTATCTTAGAAATTATAGCTCTCTTTATAGCTCAGTTTGTTGGTTACTTTA
TGGCGAGTCGCTATATCAAGCCTTTGGAACGTTTGCACGATGCAATCACTACACGTGCCAATAATTTGAAAGCAGATTTC
AAACCTGTCGTTATTCAGACAGGGGATGAAATTGAGGAACTTGCAACAGTTTATAATGATATGATGATCAAGCTTAATGA
TTACGTTGATCAGCAGAAACGTTTTGTTTCCGATGTCAGTCATGAGTTACGGACGCCACTTTCAGTTTTGGATGGGCATT
TGAATCTCTTGAATCGTTGGGGGAAAAATGATCCTGAAGTGCTTGAGGAGTCTTTACAGGCCAGTATAGAAGAAGTTAGT
ACGATGAGAACGATGTTGGAAGAGATGCTCGCATTGGCGCGTCTTGAAAGCATTGATTTTCAAGATGAAGACCTAATCTG
TGATCCGACAGAAGTTTCGAATTTTCTTAAGAAAAATTTTCTACTCATCCATCCTGATTTAAAGTTAACTGTTGAAAATG
ACTTGCCATCAGGAAGATTAGCACATATATATCCCAACCATTATGAGCAAGGTTTGAAAATATTGATTGATAATGCGATA
AAATACTCGCCTGAAGATCGTCAAGAAGTCAAGATACATCTTGAAGAAGATGATGAATATATCATTACAACTGTGGGGGA
CCGTGGTTATGGTATTAGCCAAGAAGATTTAAAACATGTATTTGAACGTTTCTTCCGTGCGGATAAAGCACGAAATCGAG
ATATAGGAGGAACTGGGCTTGGGCTATCTATTATTCAACGTATAGTGGAGAACTATGAGGGAGATGTTAGCGTGACTTCC
GTTGTAGGAGAGGGTTCAAAATTTACTTTAAAAATTCCTAAGATTAAATAA
ATGGTAAAATTTTTTGATTCTAAGAAGAAAAAAACAGAAAGTCTTCCAGAGCGTAAGCGGAGCATCATGCTACGTTGGGC
ATTTGCAAATACGATTTTTTGTTTTATTACTTTCACTATTTTTACAGTATTGGTTTATCAACTAACGATAACTACTTTCA
TCAATTCTGAAAAAGAGGATATGATGAGGGCTTTAAATAATGTTGAACAAAGTCTGTCCCAATCGGTAAACAAACTGTCA
GAAGAAAATCTTGCGAATTATTTGGCTTATGCCAAAGGCTATACAGCCTCCAGTCAGGGAAGAGAAAATGAACTTGAAAC
ACTAGGAAGTATGATTGGTTCAAGAAAGTCCTTTTATGTCTTCGATGTAGGTGAGAACCTGATTTACTCGACCAATTCGT
ATGGTTTTCGTCTAAGGAAAGATGTGGGTGATTCATCGCAAGCTGTACGTACATTTGGCGAATATTCTGGTTATTTGGTT
GAGCGACCCGTGCATTCTAAAAAAACGGGAGAACTGATCGGCTATGTACAGGCTTTTTATGATATGAGCTATTATTATAG
TGTGCGTACAAAGCTACTTGTTGCCTTGATTATCTTAGAAATTATAGCTCTCTTTATAGCTCAGTTTGTTGGTTACTTTA
TGGCGAGTCGCTATATCAAGCCTTTGGAACGTTTGCACGATGCAATCACTACACGTGCCAATAATTTGAAAGCAGATTTC
AAACCTGTCGTTATTCAGACAGGGGATGAAATTGAGGAACTTGCAACAGTTTATAATGATATGATGATCAAGCTTAATGA
TTACGTTGATCAGCAGAAACGTTTTGTTTCCGATGTCAGTCATGAGTTACGGACGCCACTTTCAGTTTTGGATGGGCATT
TGAATCTCTTGAATCGTTGGGGGAAAAATGATCCTGAAGTGCTTGAGGAGTCTTTACAGGCCAGTATAGAAGAAGTTAGT
ACGATGAGAACGATGTTGGAAGAGATGCTCGCATTGGCGCGTCTTGAAAGCATTGATTTTCAAGATGAAGACCTAATCTG
TGATCCGACAGAAGTTTCGAATTTTCTTAAGAAAAATTTTCTACTCATCCATCCTGATTTAAAGTTAACTGTTGAAAATG
ACTTGCCATCAGGAAGATTAGCACATATATATCCCAACCATTATGAGCAAGGTTTGAAAATATTGATTGATAATGCGATA
AAATACTCGCCTGAAGATCGTCAAGAAGTCAAGATACATCTTGAAGAAGATGATGAATATATCATTACAACTGTGGGGGA
CCGTGGTTATGGTATTAGCCAAGAAGATTTAAAACATGTATTTGAACGTTTCTTCCGTGCGGATAAAGCACGAAATCGAG
ATATAGGAGGAACTGGGCTTGGGCTATCTATTATTCAACGTATAGTGGAGAACTATGAGGGAGATGTTAGCGTGACTTCC
GTTGTAGGAGAGGGTTCAAAATTTACTTTAAAAATTCCTAAGATTAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| covS | Lactococcus lactis subsp. lactis strain DGCC12653 |
55.332 |
100 |
0.554 |