Detailed information NTG0943049

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: ACFION_RS00870
• Genome accession: NZ_CP170399
• Coordinates: 187268..189373 (-)
• Length: 701 a.a.
• NCBI ID: WP_001058988.1
• Uniprot ID: Q8NUR7
• Organism: Staphylococcus aureus strain t127
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 182268..194373

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFION_RS00855	-	184783..185010 (+)	228	WP_000932073.1	FeoA family protein	-
ACFION_RS00860	feoB	185022..187016 (+)	1995	WP_410531244.1	ferrous iron transport protein B	-
ACFION_RS00865	-	187029..187199 (+)	171	WP_000111118.1	FeoB-associated Cys-rich membrane protein	-
ACFION_RS00870	clpE	187268..189373 (-)	2106	WP_001058988.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
ACFION_RS00875	-	189782..190303 (+)	522	WP_000455993.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
ACFION_RS00880	-	190473..191639 (-)	1167	WP_000151982.1	hydroxymethylglutaryl-CoA synthase	-
ACFION_RS00885	-	191893..193173 (+)	1281	WP_001180324.1	hydroxymethylglutaryl-CoA reductase, degradative	-
ACFION_RS00890	-	193311..193742 (-)	432	WP_000455861.1	CHAP domain-containing protein	-
ACFION_RS00895	-	194131..194349 (-)	219	WP_000011687.1	sterile alpha motif-like domain-containing protein	-

Sequence

Protein

• Length: 701 a.a.
• Molecular weight: 77836.22 Da
• Isoelectric Point: 4.6056

>NTDB_id=943049 ACFION_RS00870 WP_001058988.1 187268..189373(-) (clpE) [Staphylococcus aureus strain t127]
MNNGFFNSDFDSIFRRMMQDMQGSNQVGNKKYYINGKEVSPEELAQLTQQGGNHSAEQSAQAFQQAAQRQQGQQGGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISV
DISSLEAGTQYRGAFEENIQKLIEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAVDKVETEKRISELENDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGNDAEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK

Nucleotide

• Length: 2106 bp

>NTDB_id=943049 ACFION_RS00870 WP_001058988.1 187268..189373(-) (clpE) [Staphylococcus aureus strain t127]
ATGAATAACGGTTTTTTCAATAGCGACTTTGATTCAATTTTCCGAAGAATGATGCAAGATATGCAAGGTTCAAATCAAGT
CGGTAACAAAAAGTACTATATTAATGGTAAAGAAGTTTCACCTGAAGAACTAGCGCAACTCACACAACAAGGTGGCAATC
ACTCTGCTGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACAAAGACAACAAGGGCAACAAGGTGGCAACGGCAATTAT
TTAGAACAAATTGGTCGTAACCTTACGCAAGAAGCACGTGACGGTTTATTAGATCCAGTCATTGGTCGTGATAAAGAAAT
TCAAGAAACTGCTGAAGTCTTAAGTAGACGAACTAAAAACAATCCTATATTAGTTGGAGAAGCTGGTGTTGGTAAAACTG
CGATTGTTGAAGGTTTAGCACAGGCAATCGTTGAAGGAAATGTACCAGCAGCAATCAAAGACAAAGAAATTATTTCTGTA
GATATTTCATCATTAGAAGCTGGAACGCAATATCGTGGTGCTTTTGAAGAAAATATTCAAAAATTAATCGAAGGTGTTAA
ATCTTCACAAAATGCCGTATTATTCTTTGATGAAATCCATCAAATTATCGGTTCAGGTGCCACAGGAAGTGATTCAGGTA
GCAAAGGGTTATCTGATATTTTGAAACCTGCATTAAGTCGTGGTGAAATTTCAATTATTGGTGCAACAACACAAGATGAA
TATCGAAACAATATTCTTAAAGATGCTGCATTAACGCGCAGATTTAATGAAGTACTTGTTAATGAACCAAGCGCTAAAGA
TACTGTTGAAATTTTAAAAGGTATTCGCGAAAAATTCGAAGAACACCATCAAGTAAAATTACCAGATGACGTATTAAAAG
CATGTGTTGACTTATCAATTCAATATATTCCACAACGATTATTACCAGATAAAGCAATCGATGTGTTAGATATTACAGCA
GCACATTTATCTGCGCAAAGTCCAGCTGTCGATAAAGTTGAAACTGAAAAACGAATTTCTGAATTAGAAAATGATAAACG
TAAAGCGGTAAGTGCTGAAGAATATAAAAAAGCTGACGACATTCAAAATGAAATCAAATCATTACAAGATAAATTAGAAA
ATAGTAATGGTGAACATACTGCTGTTGCTACAGTTCATGATATTTCAGATACTATTCAACGATTAACTGGTATTCCAGTT
TCTCAAATGGATGATAACGATATTGAACGTTTAAAAAATATTTCTAATCGTTTAAGAAGTAAAATCATAGGTCAAGATCA
AGCTGTAGAAATGGTTTCACGTGCAATTCGCCGTAATCGTGCTGGGTTTGATGACGGCAACCGCCCAATTGGCAGTTTCC
TATTTGTTGGCCCTACTGGTGTTGGTAAAACAGAGCTTGCTAAACAATTAGCAATTGATCTATTTGGTAATAAAGATGCA
CTGATTCGACTTGATATGAGTGAATATAGTGACACAACAGCTGTTTCAAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGATGACAATTCAAACACGTTAACTGAAAAAGTACGCCGTAATCCATACTCAGTCATTCTATTTGATGAAATCGAAA
AAGCAAATCCACAAATTTTAACATTGTTATTACAAGTAATGGATGATGGTAATTTGACTGATGGTCAAGGTAATGTCATC
AACTTTAAAAATACAATTATTATTTGTACATCAAATGCTGGCTTTGGCAATGGCAATGACGCTGAAGAAAAAGATATTAT
GCACGAAATGAAAAAATTCTTCCGCCCTGAATTCCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTGCAAGATATCGTCAACTTATTATTAGACGATGTACAAGTTACATTAGATAAAAAAGGTATTACGATGGACGTT
TCTCAAGATGCGAAAGATTGGTTAATTGAAGAAGGCTATGATGAAGAATTAGGTGCACGTCCATTAAGACGTATTGTTGA
ACAGCAAGTACGTGACAAAATTACAGATTACTATTTAGATCATACAGACGTTAAACATGTGGATATAGATGTTGAGGATA
ACGAATTAGTCGTAAAAGGTAAATAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (264-363)

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

3D structure

• AlphaFold DB: Q8NUR7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	48.834	91.726	0.448
clpE	Streptococcus pneumoniae Rx1	48.298	88.017	0.425
clpE	Streptococcus pneumoniae D39	48.298	88.017	0.425
clpE	Streptococcus pneumoniae R6	48.298	88.017	0.425
clpE	Streptococcus pneumoniae TIGR4	48.298	88.017	0.425
clpC	Lactococcus lactis subsp. cremoris KW2	46.815	89.586	0.419
clpC	Bacillus subtilis subsp. subtilis str. 168	44.564	93.153	0.415
clpC	Streptococcus thermophilus LMD-9	44.392	90.3	0.401
clpC	Streptococcus thermophilus LMG 18311	44.076	90.3	0.398
clpC	Streptococcus pneumoniae TIGR4	44.175	88.16	0.389
clpC	Streptococcus pneumoniae Rx1	44.175	88.16	0.389
clpC	Streptococcus pneumoniae D39	44.175	88.16	0.389
clpC	Streptococcus mutans UA159	43.577	87.732	0.382
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.294	92.582	0.382