Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   V8H05_RS10675 Genome accession   NZ_CP146213
Coordinates   2122742..2123785 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus strain KWT 2019-23549     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2117742..2128785
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V8H05_RS10645 (V8H05_10645) - 2118160..2119416 (-) 1257 WP_001795438.1 aminopeptidase -
  V8H05_RS10650 (V8H05_10650) - 2119419..2119619 (-) 201 WP_000180461.1 DUF1128 family protein -
  V8H05_RS10655 (V8H05_10655) - 2119766..2120230 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  V8H05_RS10660 (V8H05_10660) - 2120237..2120512 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  V8H05_RS10665 (V8H05_10665) - 2120790..2122007 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  V8H05_RS10670 (V8H05_10670) vraR 2122123..2122752 (-) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  V8H05_RS10675 (V8H05_10675) vraS 2122742..2123785 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  V8H05_RS10680 (V8H05_10680) liaF 2123782..2124483 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  V8H05_RS10685 (V8H05_10685) - 2124498..2124884 (-) 387 WP_001110179.1 hypothetical protein -
  V8H05_RS10690 (V8H05_10690) map 2125101..2125859 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  V8H05_RS10695 (V8H05_10695) - 2126446..2127432 (+) 987 WP_000999713.1 aromatic acid exporter family protein -
  V8H05_RS10700 (V8H05_10700) - 2127863..2128276 (-) 414 WP_001549145.1 hypothetical protein -
  V8H05_RS10705 (V8H05_10705) - 2128305..2128415 (-) 111 WP_001790257.1 hypothetical protein -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=942065 V8H05_RS10675 WP_001017131.1 2122742..2123785(-) (vraS) [Staphylococcus aureus strain KWT 2019-23549]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=942065 V8H05_RS10675 WP_001017131.1 2122742..2123785(-) (vraS) [Staphylococcus aureus strain KWT 2019-23549]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1