Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | V8H04_RS00185 | Genome accession | NZ_CP146210 |
| Coordinates | 41002..42630 (-) | Length | 542 a.a. |
| NCBI ID | WP_338616593.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain KWT 2020-26218 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 41003..91857 | 41002..42630 | flank | -1627 |
Gene organization within MGE regions
Location: 41002..91857
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V8H04_RS00185 (V8H04_00185) | ccrB | 41002..42630 (-) | 1629 | WP_338616593.1 | recombinase family protein | Machinery gene |
| V8H04_RS00190 (V8H04_00190) | ccrA | 42652..44001 (-) | 1350 | WP_338616594.1 | recombinase family protein | Machinery gene |
| V8H04_RS00195 (V8H04_00195) | - | 44235..46028 (-) | 1794 | WP_338616595.1 | DUF927 domain-containing protein | - |
| V8H04_RS00200 (V8H04_00200) | - | 46028..46324 (-) | 297 | WP_000273824.1 | single-stranded DNA-binding protein | - |
| V8H04_RS00205 (V8H04_00205) | - | 46517..47563 (-) | 1047 | WP_002454338.1 | hypothetical protein | - |
| V8H04_RS00210 (V8H04_00210) | - | 47835..48906 (-) | 1072 | Protein_39 | IS3 family transposase | - |
| V8H04_RS00215 (V8H04_00215) | - | 49073..53188 (-) | 4116 | WP_338637844.1 | E domain-containing protein | - |
| V8H04_RS00220 (V8H04_00220) | - | 53724..54029 (+) | 306 | WP_000677987.1 | hypothetical protein | - |
| V8H04_RS00225 (V8H04_00225) | - | 54227..55090 (+) | 864 | WP_000680579.1 | hypothetical protein | - |
| V8H04_RS00230 (V8H04_00230) | - | 55198..56671 (+) | 1474 | Protein_43 | DUF6038 family protein | - |
| V8H04_RS00235 (V8H04_00235) | - | 56898..57998 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| V8H04_RS00240 (V8H04_00240) | - | 57991..58362 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| V8H04_RS00245 (V8H04_00245) | - | 58359..59648 (+) | 1290 | Protein_46 | DUF5906 domain-containing protein | - |
| V8H04_RS00250 (V8H04_00250) | - | 59693..60367 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| V8H04_RS00255 (V8H04_00255) | - | 60650..61996 (+) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| V8H04_RS00260 (V8H04_00260) | merR | 62296..62703 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| V8H04_RS00265 (V8H04_00265) | - | 62720..63073 (+) | 354 | WP_000746201.1 | TlpA disulfide reductase family protein | - |
| V8H04_RS00270 (V8H04_00270) | - | 63070..63750 (+) | 681 | WP_000010352.1 | cytochrome c biogenesis protein CcdA | - |
| V8H04_RS00275 (V8H04_00275) | merT | 63838..64224 (+) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| V8H04_RS00280 (V8H04_00280) | merA | 64282..65925 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| V8H04_RS00285 (V8H04_00285) | merB | 66007..66657 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| V8H04_RS00290 (V8H04_00290) | - | 66852..67367 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| V8H04_RS00295 (V8H04_00295) | - | 67486..68160 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| V8H04_RS00300 (V8H04_00300) | - | 68244..68585 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| V8H04_RS00305 (V8H04_00305) | - | 69422..70165 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| V8H04_RS00310 (V8H04_00310) | - | 70262..70690 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| V8H04_RS00315 (V8H04_00315) | mecA | 70736..72745 (-) | 2010 | WP_338616602.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| V8H04_RS00320 (V8H04_00320) | mecR1 | 72842..74599 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| V8H04_RS00325 (V8H04_00325) | mecI | 74599..74970 (+) | 372 | Protein_62 | mecA-type methicillin resistance repressor MecI | - |
| V8H04_RS00330 (V8H04_00330) | psm-mec | 75055..75123 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| V8H04_RS00335 (V8H04_00335) | - | 75443..76591 (+) | 1149 | WP_150854453.1 | ROK family transcriptional regulator | - |
| V8H04_RS00340 (V8H04_00340) | cstB | 76705..78039 (-) | 1335 | Protein_65 | persulfide dioxygenase-sulfurtransferase CstB | - |
| V8H04_RS00345 (V8H04_00345) | - | 78071..79135 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| V8H04_RS00350 (V8H04_00350) | cstR | 79271..79531 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| V8H04_RS00355 (V8H04_00355) | - | 79531..80169 (+) | 639 | Protein_68 | sulfite exporter TauE/SafE family protein | - |
| V8H04_RS00360 (V8H04_00360) | - | 80443..81060 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| V8H04_RS00365 (V8H04_00365) | - | 81141..83556 (-) | 2416 | Protein_70 | heavy metal translocating P-type ATPase | - |
| V8H04_RS00370 (V8H04_00370) | - | 83549..83914 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| V8H04_RS00375 (V8H04_00375) | - | 84110..84487 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| V8H04_RS00380 (V8H04_00380) | - | 84494..86386 (-) | 1893 | WP_338613460.1 | site-specific integrase | - |
| V8H04_RS00385 (V8H04_00385) | - | 86581..86904 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| V8H04_RS00390 (V8H04_00390) | - | 86897..87103 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| V8H04_RS00395 (V8H04_00395) | - | 87105..87626 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| V8H04_RS00400 (V8H04_00400) | - | 87645..87956 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| V8H04_RS00405 (V8H04_00405) | - | 88041..88391 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| V8H04_RS00410 (V8H04_00410) | ccrB | 88862..90490 (-) | 1629 | WP_338616604.1 | recombinase family protein | Machinery gene |
| V8H04_RS00415 (V8H04_00415) | ccrA | 90511..91857 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62609.70 Da Isoelectric Point: 9.8778
>NTDB_id=941982 V8H04_RS00185 WP_338616593.1 41002..42630(-) (ccrB) [Staphylococcus aureus strain KWT 2020-26218]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVARVNQENKVDGAALHHDIAYKQQQYD
EVQTKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKSLFDAKQISKLLQHIFQDIKHMEKSRLK
ALYLSVIDRINIRKDDNHKKQFYVTLKLNNEVIKQVFNDTPLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVARVNQENKVDGAALHHDIAYKQQQYD
EVQTKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKSLFDAKQISKLLQHIFQDIKHMEKSRLK
ALYLSVIDRINIRKDDNHKKQFYVTLKLNNEVIKQVFNDTPLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=941982 V8H04_RS00185 WP_338616593.1 41002..42630(-) (ccrB) [Staphylococcus aureus strain KWT 2020-26218]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAGGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTTAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGGCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACAACGAATACACTTAAAGAC
GGAACCAAGAAACGCATACGTTACTATTCATGTAGTAATTTTCGCAACAAGGGGTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTTG
TAGCACGTGTTAATCAAGAAAATAAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAACCAAACTAAATAACTTGATTAAAACCATAGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAACCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGTCTT
TATTTGATGCCAAACAAATCAGTAAACTATTACAACACATCTTTCAAGATATTAAGCACATGGAAAAATCTCGACTCAAA
GCATTGTACCTATCAGTGATTGATCGTATTAATATTAGAAAAGATGACAATCATAAAAAACAGTTCTATGTCACACTCAA
ACTTAATAATGAAGTAATTAAACAGGTTTTCAATGATACTCCTCTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TACCACAAACCCTATATCTTACTATTTAA
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAGGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTTAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGGCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTCCTATGCCAAAGGACATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACAACGAATACACTTAAAGAC
GGAACCAAGAAACGCATACGTTACTATTCATGTAGTAATTTTCGCAACAAGGGGTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTCGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTTG
TAGCACGTGTTAATCAAGAAAATAAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAACCAAACTAAATAACTTGATTAAAACCATAGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAACCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGTCTT
TATTTGATGCCAAACAAATCAGTAAACTATTACAACACATCTTTCAAGATATTAAGCACATGGAAAAATCTCGACTCAAA
GCATTGTACCTATCAGTGATTGATCGTATTAATATTAGAAAAGATGACAATCATAAAAAACAGTTCTATGTCACACTCAA
ACTTAATAATGAAGTAATTAAACAGGTTTTCAATGATACTCCTCTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TACCACAAACCCTATATCTTACTATTTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
96.494 |
100 |
0.965 |