Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ACE2AN_RS03765 Genome accession   NZ_CP169564
Coordinates   735922..738180 (-) Length   752 a.a.
NCBI ID   WP_081528492.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 6_2F1     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 730922..743180
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACE2AN_RS03745 tnpB 733376..733612 (-) 237 WP_000586645.1 IS66 family insertion sequence element accessory protein TnpB -
  ACE2AN_RS03750 - 733873..734172 (-) 300 WP_000767195.1 DUF1827 family protein -
  ACE2AN_RS03755 - 734337..734792 (-) 456 WP_001809363.1 NUDIX hydrolase -
  ACE2AN_RS03760 - 734869..735715 (+) 847 Protein_743 IS630 family transposase -
  ACE2AN_RS03765 clpE 735922..738180 (-) 2259 WP_081528492.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  ACE2AN_RS03770 - 738409..738639 (-) 231 WP_000443573.1 YkuJ family protein -
  ACE2AN_RS03775 - 738829..739512 (+) 684 WP_001011637.1 amino acid ABC transporter permease -
  ACE2AN_RS03780 - 739512..740246 (+) 735 WP_000140941.1 amino acid ABC transporter ATP-binding protein -
  ACE2AN_RS03785 - 740400..741257 (+) 858 WP_000192085.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  ACE2AN_RS03790 - 741399..742271 (+) 873 WP_000864690.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83880.29 Da        Isoelectric Point: 5.4492

>NTDB_id=939557 ACE2AN_RS03765 WP_081528492.1 735922..738180(-) (clpE) [Streptococcus pneumoniae strain 6_2F1]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPHIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=939557 ACE2AN_RS03765 WP_081528492.1 735922..738180(-) (clpE) [Streptococcus pneumoniae strain 6_2F1]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCATATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGACGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACAGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GTCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGATAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

99.867

100

0.999
  clpE Streptococcus pneumoniae D39

99.867

100

0.999
  clpE Streptococcus pneumoniae R6

99.867

100

0.999
  clpE Streptococcus pneumoniae TIGR4

99.734

100

0.997
  clpE Streptococcus mutans UA159

82.731

99.335

0.822
  clpC Lactococcus lactis subsp. cremoris KW2

76.776

97.34

0.747
  clpC Bacillus subtilis subsp. subtilis str. 168

51.714

89.229

0.461
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus mutans UA159

46.571

83.378

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386