Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | V6C68_RS12585 | Genome accession | NZ_CP145228 |
| Coordinates | 2554915..2556264 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815640.1 | Uniprot ID | - |
| Organism | Staphylococcus capitis subsp. urealyticus strain Sc1365695 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2546500..2597103 | 2554915..2556264 | within | 0 |
Gene organization within MGE regions
Location: 2546500..2597103
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V6C68_RS12545 (V6C68_12510) | mecA | 2546500..2548509 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| V6C68_RS12550 (V6C68_12515) | - | 2548606..2549592 (+) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| V6C68_RS12555 (V6C68_12520) | - | 2549564..2549824 (+) | 261 | WP_001549961.1 | type I restriction enzyme endonuclease domain-containing protein | - |
| V6C68_RS12560 (V6C68_12525) | - | 2549815..2551422 (-) | 1608 | Protein_2422 | IS1182 family transposase | - |
| V6C68_RS12565 (V6C68_12530) | - | 2551474..2551980 (-) | 507 | WP_367027663.1 | DUF1643 domain-containing protein | - |
| V6C68_RS12570 (V6C68_12535) | - | 2551995..2552306 (-) | 312 | WP_000700851.1 | DUF960 family protein | - |
| V6C68_RS12575 (V6C68_12540) | - | 2552393..2552743 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| V6C68_RS12580 (V6C68_12545) | ccrB | 2553265..2554893 (-) | 1629 | WP_001186608.1 | recombinase family protein | Machinery gene |
| V6C68_RS12585 (V6C68_12550) | ccrA | 2554915..2556264 (-) | 1350 | WP_000815640.1 | recombinase family protein | Machinery gene |
| V6C68_RS12590 (V6C68_12555) | - | 2556498..2558285 (-) | 1788 | WP_000122620.1 | DUF927 domain-containing protein | - |
| V6C68_RS12595 (V6C68_12560) | - | 2558285..2558575 (-) | 291 | WP_001036438.1 | hypothetical protein | - |
| V6C68_RS12600 (V6C68_12565) | - | 2558714..2559763 (+) | 1050 | WP_000613248.1 | hypothetical protein | - |
| V6C68_RS12605 (V6C68_12570) | - | 2559847..2560521 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| V6C68_RS12610 (V6C68_12575) | - | 2560553..2560792 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| V6C68_RS12615 (V6C68_12580) | - | 2561207..2562463 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| V6C68_RS12620 (V6C68_12585) | - | 2562906..2563451 (-) | 546 | WP_016931282.1 | YdhK family protein | - |
| V6C68_RS12625 (V6C68_12590) | - | 2563469..2565529 (-) | 2061 | WP_016931281.1 | heavy metal translocating P-type ATPase | - |
| V6C68_RS12630 (V6C68_12595) | - | 2565798..2566115 (+) | 318 | WP_002434474.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| V6C68_RS12635 (V6C68_12600) | arsB | 2566112..2567404 (+) | 1293 | WP_171817092.1 | arsenite efflux transporter membrane subunit ArsB | - |
| V6C68_RS12640 (V6C68_12605) | arsC | 2567422..2567823 (+) | 402 | WP_002434455.1 | arsenate reductase (thioredoxin) | - |
| V6C68_RS12645 (V6C68_12610) | - | 2567843..2568184 (-) | 342 | WP_002469817.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| V6C68_RS12650 (V6C68_12615) | - | 2568203..2568820 (-) | 618 | WP_002434082.1 | CadD family cadmium resistance transporter | - |
| V6C68_RS12655 (V6C68_12620) | - | 2569358..2569723 (-) | 366 | WP_002434567.1 | hypothetical protein | - |
| V6C68_RS12660 (V6C68_12625) | - | 2569732..2570736 (-) | 1005 | WP_002434486.1 | NADP-dependent oxidoreductase | - |
| V6C68_RS12665 (V6C68_12630) | - | 2570740..2571405 (-) | 666 | WP_002434095.1 | NAD(P)-binding oxidoreductase | - |
| V6C68_RS12670 (V6C68_12635) | - | 2571427..2572110 (-) | 684 | WP_002434046.1 | type 1 glutamine amidotransferase domain-containing protein | - |
| V6C68_RS12675 (V6C68_12640) | - | 2572188..2572535 (+) | 348 | WP_002434548.1 | MerR family transcriptional regulator | - |
| V6C68_RS12680 (V6C68_12645) | - | 2572673..2573347 (+) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| V6C68_RS12685 (V6C68_12650) | - | 2573409..2573771 (-) | 363 | Protein_2447 | HTH domain-containing protein | - |
| V6C68_RS12690 (V6C68_12655) | - | 2573941..2574387 (-) | 447 | WP_002504705.1 | JAB domain-containing protein | - |
| V6C68_RS12695 (V6C68_12660) | - | 2574408..2574914 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| V6C68_RS12700 (V6C68_12665) | - | 2574930..2575241 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| V6C68_RS12705 (V6C68_12670) | - | 2575337..2575675 (-) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| V6C68_RS12710 (V6C68_12675) | - | 2575781..2577457 (-) | 1677 | WP_002504707.1 | recombinase family protein | - |
| V6C68_RS12715 (V6C68_12680) | - | 2577682..2579325 (-) | 1644 | WP_141489472.1 | DUF5906 domain-containing protein | - |
| V6C68_RS12720 (V6C68_12685) | - | 2579322..2579693 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| V6C68_RS12725 (V6C68_12690) | - | 2579686..2580795 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| V6C68_RS12730 (V6C68_12695) | - | 2580965..2582977 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| V6C68_RS12735 (V6C68_12700) | - | 2583139..2584068 (-) | 930 | WP_002504713.1 | HTH domain-containing protein | - |
| V6C68_RS12740 (V6C68_12705) | - | 2584149..2584577 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| V6C68_RS12745 (V6C68_12710) | - | 2584637..2585311 (-) | 675 | Protein_2459 | IS6 family transposase | - |
| V6C68_RS12750 (V6C68_12715) | - | 2585522..2586712 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| V6C68_RS12755 (V6C68_12720) | - | 2586699..2587565 (+) | 867 | WP_001052247.1 | LysR family transcriptional regulator | - |
| V6C68_RS12760 (V6C68_12725) | - | 2587578..2588648 (+) | 1071 | WP_002499602.1 | nitronate monooxygenase | - |
| V6C68_RS12765 (V6C68_12730) | - | 2588813..2589172 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| V6C68_RS12770 (V6C68_12735) | - | 2589410..2590183 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| V6C68_RS12775 (V6C68_12740) | - | 2590869..2591702 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| V6C68_RS12780 (V6C68_12745) | - | 2591739..2592065 (-) | 327 | WP_000624048.1 | helix-turn-helix transcriptional regulator | - |
| V6C68_RS12785 (V6C68_12750) | - | 2592612..2593232 (-) | 621 | WP_000673114.1 | hypothetical protein | - |
| V6C68_RS12790 (V6C68_12755) | - | 2593361..2593732 (-) | 372 | WP_001549968.1 | HNH endonuclease | - |
| V6C68_RS12795 (V6C68_12760) | - | 2593729..2593866 (-) | 138 | WP_001791883.1 | hypothetical protein | - |
| V6C68_RS12800 (V6C68_12765) | cstB | 2593922..2595240 (+) | 1319 | Protein_2470 | persulfide dioxygenase-sulfurtransferase CstB | - |
| V6C68_RS12805 (V6C68_12770) | - | 2595613..2597103 (-) | 1491 | WP_000554504.1 | RNA-binding domain-containing protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52663.34 Da Isoelectric Point: 9.9639
>NTDB_id=937985 V6C68_RS12585 WP_000815640.1 2554915..2556264(-) (ccrA) [Staphylococcus capitis subsp. urealyticus strain Sc1365695]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=937985 V6C68_RS12585 WP_000815640.1 2554915..2556264(-) (ccrA) [Staphylococcus capitis subsp. urealyticus strain Sc1365695]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
97.55 |
100 |
0.976 |
| ccrA | Staphylococcus aureus COL |
75.947 |
100 |
0.759 |