Detailed information NTG0093654

Bioinformatically predicted

Overview

• Name: braS
• Type: Regulator
• Locus tag: M2038_RS13960
• Genome accession: NZ_AP025693
• Coordinates: 2775369..2776256 (-)
• Length: 295 a.a.
• NCBI ID: WP_000143419.1
• Uniprot ID: A0A266CLT2
• Organism: Staphylococcus aureus strain JICS127
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2770369..2781256

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M2038_RS13930	-	2770388..2770480 (+)	93	WP_010956583.1	hypothetical protein	-
M2038_RS13935 (JICS127ACC_2628)	-	2770588..2771085 (-)	498	WP_001065268.1	glutathione peroxidase	-
M2038_RS13940	-	2771095..2771355 (-)	261	WP_001789910.1	hypothetical protein	-
M2038_RS13945	-	2771737..2771850 (-)	114	WP_001791776.1	hypothetical protein	-
M2038_RS13950 (JICS127ACC_2630)	-	2772509..2774509 (-)	2001	WP_000776751.1	ABC transporter permease	-
M2038_RS13955 (JICS127ACC_2631)	-	2774506..2775261 (-)	756	WP_000923760.1	ABC transporter ATP-binding protein	-
M2038_RS13960 (JICS127ACC_2632)	braS	2775369..2776256 (-)	888	WP_000143419.1	nisin susceptibility-associated two-component system sensor histidine kinase NsaS	Regulator
M2038_RS13965 (JICS127ACC_2633)	braR	2776267..2776932 (-)	666	WP_000697886.1	nisin susceptibility-associated two-component system response regulator NsaR	Regulator
M2038_RS13970 (JICS127ACC_2634)	-	2776958..2777158 (-)	201	WP_000604728.1	hypothetical protein	-
M2038_RS13975 (JICS127ACC_2635)	-	2777356..2778780 (+)	1425	WP_000953744.1	alkaline phosphatase	-
M2038_RS14830 (JICS127ACC_2636)	-	2778840..2778941 (-)	102	WP_000731972.1	SE2200 family small protein	-
M2038_RS13985 (JICS127ACC_2637)	-	2779063..2779518 (-)	456	WP_000106185.1	MarR family winged helix-turn-helix transcriptional regulator	-
M2038_RS13990 (JICS127ACC_2638)	-	2779763..2780524 (-)	762	WP_000323455.1	alpha/beta hydrolase family protein	-

Sequence

Protein

• Length: 295 a.a.
• Molecular weight: 34019.28 Da
• Isoelectric Point: 6.0874

>NTDB_id=93654 M2038_RS13960 WP_000143419.1 2775369..2776256(-) (braS) [Staphylococcus aureus strain JICS127]
MTFLKSITQEIAIVIVIFALFGLMFYLYHLPLEAYLLALGVILLLLLIFIGIKYLSFVKTISQQQQIENLENALYQLKNE
QIEYKNDVESYFLTWVHQMKTPITAAQLLLERDEPNVVNRVRQEVIQIDNYTSLALSYLKLLNETSDISVTKISINNIIR
PIIMKYSIQFIDQKTKIHYEPCHHEVLTDVRWTSLMIEQLINNALKYARGKDIWIEFDEQSNQLHVKDNGIGISEADLPK
IFDKGYSGYNGQRQSNSSGIGLFIVKQISTHTNHPVSVVSKQNEGTTFTIQFPDE

Nucleotide

• Length: 888 bp

>NTDB_id=93654 M2038_RS13960 WP_000143419.1 2775369..2776256(-) (braS) [Staphylococcus aureus strain JICS127]
ATGACCTTTCTTAAAAGTATTACTCAGGAAATAGCAATAGTCATAGTTATTTTTGCTTTGTTTGGCTTAATGTTTTACCT
GTATCATTTGCCATTAGAAGCATATTTACTAGCACTTGGCGTTATTTTATTATTATTACTCATATTCATAGGTATTAAAT
ATTTAAGTTTTGTAAAAACTATAAGCCAACAACAACAAATTGAAAACTTAGAAAATGCGTTGTATCAGCTTAAAAATGAA
CAAATTGAATATAAAAATGATGTAGAGAGCTACTTTTTAACATGGGTACATCAAATGAAAACACCCATTACTGCAGCACA
ACTGTTACTTGAAAGAGATGAGCCTAATGTTGTTAATCGTGTTCGTCAAGAGGTTATTCAAATTGATAACTATACAAGTT
TAGCACTTAGTTATTTAAAGTTATTAAATGAAACTTCTGATATTTCTGTCACTAAAATTTCGATTAATAATATCATTCGC
CCAATTATTATGAAATATTCAATACAGTTTATTGATCAAAAAACAAAAATCCATTATGAACCTTGTCATCACGAAGTATT
AACTGACGTTAGATGGACCTCTTTAATGATAGAACAATTAATAAATAATGCACTTAAGTATGCGAGAGGTAAAGATATAT
GGATTGAATTTGATGAGCAATCCAATCAATTACACGTAAAAGATAATGGTATCGGTATTAGTGAAGCGGACTTGCCTAAA
ATATTTGATAAGGGCTATTCAGGTTATAATGGCCAGCGCCAAAGTAACTCAAGTGGGATTGGTTTATTTATCGTAAAACA
AATTTCAACACACACAAACCATCCTGTTTCAGTCGTATCTAAACAAAATGAGGGTACAACATTTACGATTCAATTTCCAG
ATGAATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (191-294)

3D structure

• AlphaFold DB: A0A266CLT2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braS	Staphylococcus aureus N315	99.661	100	0.997