Detailed information NTG0093649

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M2038_RS10040
• Genome accession: NZ_AP025693
• Coordinates: 2031439..2032482 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JICS127
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2026439..2037482

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M2038_RS10010 (JICS127ACC_1894)	-	2026857..2028113 (-)	1257	WP_001795438.1	aminopeptidase	-
M2038_RS10015 (JICS127ACC_1895)	-	2028116..2028316 (-)	201	WP_000180461.1	DUF1128 family protein	-
M2038_RS10020 (JICS127ACC_1896)	-	2028463..2028927 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M2038_RS10025 (JICS127ACC_1897)	-	2028934..2029209 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M2038_RS10030 (JICS127ACC_1898)	-	2029487..2030704 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
M2038_RS10035 (JICS127ACC_1899)	vraR	2030820..2031449 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
M2038_RS10040 (JICS127ACC_1900)	vraS	2031439..2032482 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M2038_RS10045 (JICS127ACC_1901)	liaF	2032479..2033180 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M2038_RS10050 (JICS127ACC_1902)	-	2033195..2033581 (-)	387	WP_001110179.1	hypothetical protein	-
M2038_RS10055 (JICS127ACC_1903)	map	2033798..2034556 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
M2038_RS10060 (JICS127ACC_1904)	-	2035084..2036070 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
M2038_RS10065 (JICS127ACC_1905)	-	2036619..2037032 (-)	414	WP_001549145.1	hypothetical protein	-
M2038_RS10070	-	2037061..2037171 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=93649 M2038_RS10040 WP_001017131.1 2031439..2032482(-) (vraS) [Staphylococcus aureus strain JICS127]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=93649 M2038_RS10040 WP_001017131.1 2031439..2032482(-) (vraS) [Staphylococcus aureus strain JICS127]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1